ENDOTHELIN SUBTYPE-B RECEPTORS ARE COUPLED TO ADENYLATE-CYCLASE VIA INHIBITORY-G PROTEIN IN CULTURED BOVINE ENDOTHELIAL-CELLS

被引：18
作者：
EGUCHI, S [1 ]
HIRATA, Y [1 ]
MARUMO, F [1 ]
机构：
[1] TOKYO MED & DENT UNIV,DEPT INTERNAL MED 2,DIV ENDOCRINE HYPERTENS,1-5-45 YUSHIMA,BUNKYO KU,TOKYO 113,JAPAN
来源：
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1993年 / 22卷
关键词：
ENDOTHELIN; ET(B) RECEPTOR; ENDOTHELIAL CELL; ADENYLATE CYCLASE; GI PROTEIN;
D O I：
10.1097/00005344-199322008-00043
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We studied whether endothelin (ET) isopeptides have any effects on adenylate cyclase activity in cultured bovine endothelial cells (ECs). Both ET-1 and ET-3 dose-dependently inhibited cAMP formation stimulated by forskolin and isoproterenol, although the inhibitory effect of ET-1 was less potent than that of ET-3. In contrast, ET-1 and ET-3 almost equipotently inhibited forskolin-stimulated cAMP formation in bovine EC pre-treated with phosphoramidon, a putative ET-1-converting-enzyme inhibitor. These data suggest that endothelial ET(B) receptors are functionally coupled to adenylate cyclase, possibly via G(i) protein.
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收藏
页码：S161 / S163
页数：3
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