IS THE OSTEOCLAST CALCIUM RECEPTOR A RECEPTOR-OPERATED CALCIUM-CHANNEL

被引：37

作者：

BAX, CMR ^{[1
]}

SHANKAR, VS ^{[1
]}

MOONGA, BS ^{[1
]}

HUANG, CLH ^{[1
]}

ZAIDI, M ^{[1
]}

机构：

[1] UNIV CAMBRIDGE,PHYSIOL LAB,CAMBRIDGE CB2 3EJ,ENGLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 183卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0006-291X(92)90527-R

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Elevated extracellular calcium levels ([Ca2+]e) inhibit osteoclast function by elevating cytosolic free calcium levels ([Ca2+]i), presumably via the activation of a surface Ca2+ "receptor". It is unclear whether or not Ca2+-induced [Ca2+]i elevation involves the direct gating, by the putative "receptor", of a divalent cation channel. The results show that [Ca2+]i elevation in response to elevated [Ca2+]e comprises a distinct component of Ca2+ influx, the magnitude of which can be decreased and increased, respectively, by depolarising (100 mM-[K+]) and hyperpolarising (1 μM-[valinomycin]) the osteoclast membrane. In addition, activation of the putative Ca2+ "receptor" by elevated [Ca2+]e causes influx of the related divalent cation, magnesium (Mg2+). We suggest that Ca2+ influx induced by Ca2+ "receptor" activation is a major component of the observed [Ca2+]i response. © 1992.

引用

页码：619 / 625

页数：7

共 18 条

[1]

ARKETT SA, 1991, J BONE MINER RES, V6, P51

[2]

BENHAM CD, 1989, ION TRANSPORT, P197

[3] EXTRACELLULAR CA2+ SENSING, REGULATION OF PARATHYROID CELL-FUNCTION, AND ROLE OF CA2+ AND OTHER IONS AS EXTRACELLULAR (1ST) MESSENGERS [J].