GENETIC AND PHARMACOLOGICAL SUPPRESSION OF ONCOGENIC MUTATIONS IN RAS GENES OF YEAST AND HUMANS

被引：550
作者：
SCHAFER, WR
KIM, R
STERNE, R
THORNER, J
KIM, SH
RINE, J
机构：
[1] UNIV CALIF BERKELEY LAWRENCE BERKELEY LAB,BERKELEY,CA 94720
[2] UNIV CALIF BERKELEY,DEPT BIOCHEM,BERKELEY,CA 94720
[3] UNIV CALIF BERKELEY,DEPT CHEM,BERKELEY,CA 94720
来源：
SCIENCE | 1989年 / 245卷 / 4916期
关键词：
D O I：
10.1126/science.2569235
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
引用
收藏
页码：379 / 385
页数：7
相关论文
共 74 条
[1]   MEVINOLIN - A HIGHLY POTENT COMPETITIVE INHIBITOR OF HYDROXYMETHYLGLUTARYL-COENZYME-A REDUCTASE AND A CHOLESTEROL-LOWERING AGENT [J].
ALBERTS, AW ;
CHEN, J ;
KURON, G ;
HUNT, V ;
HUFF, J ;
HOFFMAN, C ;
ROTHROCK, J ;
LOPEZ, M ;
JOSHUA, H ;
HARRIS, E ;
PATCHETT, A ;
MONAGHAN, R ;
CURRIE, S ;
STAPLEY, E ;
ALBERSSCHONBERG, G ;
HENSENS, O ;
HIRSHFIELD, J ;
HOOGSTEEN, K ;
LIESCH, J ;
SPRINGER, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (07) :3957-3961
[2]   MOST HUMAN CARCINOMAS OF THE EXOCRINE PANCREAS CONTAIN MUTANT C-K-RAS GENES [J].
ALMOGUERA, C ;
SHIBATA, D ;
FORRESTER, K ;
MARTIN, J ;
ARNHEIM, N ;
PERUCHO, M .
CELL, 1988, 53 (04) :549-554
[3]  
ANDEREGG RJ, 1988, J BIOL CHEM, V263, P18236
[4]  
[Anonymous], UNPUB
[5]   RAS GENES [J].
BARBACID, M .
ANNUAL REVIEW OF BIOCHEMISTRY, 1987, 56 :779-827
[6]   STRUCTURAL AND FUNCTIONAL CONSERVATION BETWEEN YEAST AND HUMAN 3-HYDROXY-3-METHYLGLUTARYL COENZYME-A REDUCTASES, THE RATE-LIMITING ENZYME OF STEROL BIOSYNTHESIS [J].
BASSON, ME ;
THORSNESS, M ;
FINERMOORE, J ;
STROUD, RM ;
RINE, J .
MOLECULAR AND CELLULAR BIOLOGY, 1988, 8 (09) :3797-3808
[7]   SACCHAROMYCES-CEREVISIAE CONTAINS 2 FUNCTIONAL GENES ENCODING 3-HYDROXY-3-METHYLGLUTARYL-COENZYME-A REDUCTASE [J].
BASSON, ME ;
THORSNESS, M ;
RINE, J .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (15) :5563-5567
[8]  
BASSON ME, UNPUB
[9]   RAS PROTEINS CAN INDUCE MEIOSIS IN XENOPUS OOCYTES [J].
BIRCHMEIER, C ;
BROEK, D ;
WIGLER, M .
CELL, 1985, 43 (03) :615-621
[10]   EXPRESSION OF AN ACTIVATED RAS GENE CAUSES DEVELOPMENTAL ABNORMALITIES IN TRANSGENIC DROSOPHILA-MELANOGASTER [J].
BISHOP, JG ;
CORCES, VG .
GENES & DEVELOPMENT, 1988, 2 (05) :567-577
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