Intestinal epithelium in inflammatory bowel disease

被引：147

作者：

Coskun, Mehmet ^{[1
]}

机构：

[1] Univ Copenhagen, Herlev Hosp, Dept Gastroenterol, Med Sect 5403, Herlev Ringvej 75, DK-2730 Herlev, Denmark

来源：

FRONTIERS IN MEDICINE | 2014年 / 1卷

关键词：

barrier dysfunction; Crohn's disease; inflammatory bowel disease; intestinal epithelium; tight junctions; ulcerative colitis;

D O I：

10.3389/fmed.2014.00024

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The intestinal epithelium has a strategic position as a protective physical barrier to luminal microbiota and actively contributes to the mucosal immune system. This barrier is mainly formed by a monolayer of specialized intestinal epithelial cells (IECs) that are crucial in maintaining intestinal homeostasis. Therefore, dysregulation within the epithelial layer can increase intestinal permeability, lead to abnormalities in interactions between IECs and immune cells in underlying lamina propria, and disturb the intestinal immune homeostasis, all of which are linked to the clinical disease course of inflammatory bowel disease (IBD). Understanding the role of the intestinal epithelium in IBD pathogenesis might contribute to an improved knowledge of the inflammatory processes and the identification of potential therapeutic targets.

引用

页数：5

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