LIPOPOLYSACCHARIDE AND INTERLEUKIN-1 DEPRESS FOOD-MOTIVATED BEHAVIOR IN MICE BY A VAGAL-MEDIATED MECHANISM

被引：182
作者：
BRETDIBAT, JL [1 ]
BLUTHE, RM [1 ]
KENT, S [1 ]
KELLEY, KW [1 ]
DANTZER, R [1 ]
机构：
[1] UNIV ILLINOIS, DEPT ANIM SCI, URBANA, IL 61801 USA
来源：
BRAIN BEHAVIOR AND IMMUNITY | 1995年 / 9卷 / 03期
关键词：
D O I：
10.1006/brbi.1995.1023
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In order to assess the role of vagal nerve afferents in the decrease in food-motivated behavior induced by proinflammatory cytokines, the effects of lipopolysaccharide (LPS, 400 mu g/kg ip) and recombinant human interleukin-1 beta (IL-1, 750-1500 ng/mouse ip) were tested on nose poke for food in vagotomized and sham-operated mice. Subdiaphragmatic vagotomy attenuated the decrease in response rate induced by IL-1 and LPS. These results suggest that the peripheral immune message is transmitted to the brain via a neural rather than a humoral pathway. (C) 1995 Academic Press. Inc.
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收藏
页码：242 / 246
页数：5
相关论文
共 18 条
[1]   BLOOD TO BRAIN TRANSPORT OF INTERLEUKIN LINKS THE IMMUNE AND CENTRAL NERVOUS SYSTEMS [J].
BANKS, WA ;
KASTIN, AJ .
LIFE SCIENCES, 1991, 48 (25) :PL117-PL121
[2]  
BLATTEIS CM, 1992, PROG BRAIN RES, V91, P409
[3]  
BLUTHE RM, 1994, CR ACAD SCI III-VIE, V317, P499
[4]  
BLUTHE RM, 1992, ANN NY ACAD SCI, V650, P268
[5]   A BEHAVIORALLY ACTIVE DOSE OF LIPOPOLYSACCHARIDE INCREASES SENSORY NEUROPEPTIDES LEVELS IN MOUSE SPINAL-CORD [J].
BRETDIBAT, JL ;
KENT, S ;
COURAUD, JY ;
CREMINON, C ;
DANTZER, R .
NEUROSCIENCE LETTERS, 1994, 173 (1-2) :205-209
[6]   DIFFERENT RECEPTOR MECHANISMS MEDIATE THE PYROGENIC AND BEHAVIORAL-EFFECTS OF INTERLEUKIN-1 [J].
KENT, S ;
BLUTHE, RM ;
DANTZER, R ;
HARDWICK, AJ ;
KELLEY, KW ;
ROTHWELL, NJ ;
VANNICE, JL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (19) :9117-9120
[7]   SICKNESS BEHAVIOR AS A NEW TARGET FOR DRUG DEVELOPMENT [J].
KENT, S ;
BLUTHE, RM ;
KELLEY, KW ;
DANTZER, R .
TRENDS IN PHARMACOLOGICAL SCIENCES, 1992, 13 (01) :24-28
[8]  
KRALY FS, 1978, J COMP PHYSIOL PSYCH, V92, P999, DOI 10.1037/h0077517
[9]   SUBDIAPHRAGMATIC VAGOTOMY BLOCKS INDUCTION OF IL-1-BETA MESSENGER-RNA IN MICE BRAIN IN RESPONSE TO PERIPHERAL LPS [J].
LAYE, S ;
BLUTHE, RM ;
KENT, S ;
COMBE, C ;
MEDINA, C ;
PARNET, P ;
KELLEY, K ;
DANTZER, R .
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1995, 268 (05) :R1327-R1331
[10]   PERIPHERAL ADMINISTRATION OF LIPOPOLYSACCHARIDE INDUCES THE EXPRESSION OF CYTOKINE TRANSCRIPTS IN THE BRAIN AND PITUITARY OF MICE [J].
LAYE, S ;
PARNET, P ;
GOUJON, E ;
DANTZER, R .
MOLECULAR BRAIN RESEARCH, 1994, 27 (01) :157-162
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