UNCOUPLING OF MITOCHONDRIAL OXIDATIVE-PHOSPHORYLATION BY THALLIUM

被引：56

作者：

MELNICK, RL ^{[1
]}

MONTI, LG ^{[1
]}

MOTZKIN, M ^{[1
]}

机构：

[1] POLYTECH INST NEW YORK, DEPT LIFE SCI, BROOKLYN, NY 11201 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1976年 / 69卷 / 01期

关键词：

D O I：

10.1016/S0006-291X(76)80273-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tl in the absence of ionophores stimulates succinate oxidation rates in rat liver mitochondria. Mitochondria oxidizing ascorbate undergo large amplitude swelling in the presence of Tl, indicating that Tl is actively accumulated. Similar responses with K are possible only if valinomycin is present. Tl thus appears to act as an uncoupler of energized mitochondria, and mitochondrial membranes can differentiate Tl from K.

引用

页码：68 / 73

页数：6

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