INCORPORATION OF ALKYLTHIOL CHAINS AT C-5 OF DEOXYURIDINE

被引：45

作者：

GOODWIN, JT ^{[1
]}

GLICK, GD ^{[1
]}

机构：

[1] UNIV MICHIGAN,DEPT CHEM,ANN ARBOR,MI 48109

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 35期

关键词：

ALKYLTHIOL-MODIFIED NUCLEOSIDES; DISULFIDE CROSS-LINKS;

D O I：

10.1016/S0040-4039(00)73878-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of alkylthiol-tether homologs at C-5 of 2'-deoxyuridine have been synthesized and incorporated into DNA oligomers through solid-phase DNA phosphoramidite synthesis. DNA-ligand disulfide crosslinks have been initially addressed through formation of an n-butyl-DNA disulfide conjugate.

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页码：5549 / 5552

页数：4

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