TREATMENT OF INTERMITTENT CLAUDICATION WITH ANTIPLATELET AGENTS

被引：25

作者：

GIANSANTE, C ^{[1
]}

CALABRESE, S ^{[1
]}

FISICARO, M ^{[1
]}

FIOTTI, N ^{[1
]}

MITRI, E ^{[1
]}

机构：

[1] TRIESTE HOSP,HAEMOSTASIS & THROMBOSIS LAB,TRIESTE,ITALY

来源：

JOURNAL OF INTERNATIONAL MEDICAL RESEARCH | 1990年 / 18卷 / 05期

关键词：

aspirin; dipyridamole; intermittent claudication; platelet aggregation; Ticlopidine; xanthinol nicotinate;

D O I：

10.1177/030006059001800508

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In a double-blind study, 296 patients with intermittent claudication (Fontaine stage II) were treated with 250 mg ticlopidine twice daily, 500 mg aspirin every third day plus 75 mg dipyridamole three times daily, or 300 mg xanthinol nicotinate three times daily for 6 months. Ticlopidine and aspirin/dipyridamole, but not xanthinol nicotinate, improved platelet aggregation, reduced β-thromboglobulin, platelet factor IV and fibrinopeptide A concentrations, and increased antithrombin III concentrations and red blood cell filterability. No changes in lipid profiles, platelet count or fibrinogen were recorded following any treatment. The doppler systolic blood pressure ratio was improved in patients treated with ticlopidine or aspirin/dipyridamole, but not with xanthinol nicotinate. It is concluded that antiplatelet treatment is useful for the treatment of limb arteriopathy. © 1990, SAGE Publications. All rights reserved.

引用

页码：400 / 407

页数：8

共 25 条

[1] ASANO T, 1977, MOL PHARMACOL, V13, P400
[2] AGGREGATION OF BLOOD PLATELETS BY ADENOSINE DIPHOSPHATE AND ITS REVERSAL
BORN, GVR
[J]. NATURE, 1962, 194 (4832) : 927 - &
[3] BRUNO JJ, 1983, THROMB RES S, V4, P75
[4] CALABRESE S, 1984, Giornale della Arteriosclerosi, V9, P223
[5] BETA-THROMBOGLOBULIN, PLATELET PRODUCTION TIME AND PLATELET-FUNCTION IN VASCULAR-DISEASE
CELLA, G
ZAHAVI, J
DEHAAS, HA
KAKKAR, VV
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 1979, 43 (01) : 127 - 136
[6] COFFMAN JD, 1979, NEW ENGL J MED, V300, P713
[7] Cordaro C, 1980, Ric Clin Lab, V10 Suppl 1, P113
[8] DIPERRI T, 1988, 3 C NAZ SOC IT EM FL, P36
[9] DORMANDY JA, 1986, VASCULAR SURGERY ISS, P3
[10] Green K, 1986, Adv Prostaglandin Thromboxane Leukot Res, V16, P309

← 1 2 3 →