THE REACTION OF ALPHA-ALKOXYALLYLPHOSPHINE OXIDES WITH ALPHA,BETA-UNSATURATED CARBONYL-COMPOUNDS - AN APPROACH TO PROSTAGLANDIN PRECURSORS

被引：12

作者：

BIRSE, EF ^{[1
]}

IRONSIDE, MD ^{[1
]}

MURRAY, AW ^{[1
]}

机构：

[1] UNIV DUNDEE,DEPT CHEM,DUNDEE DD1 4HN,SCOTLAND

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 35期

关键词：

D O I：

10.1016/0040-4039(95)01218-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The regiochemistry of the reaction of alpha-methoxyallylphosphine oxides with alpha, beta unsaturated carbonyl compounds has been studied. With 2-cyclopenten-1-ones, and using a transmetallation procedure, a nucleophilic beta-alkylation-electrophilic alpha-alkylation strategy which leads to advanced prostlgandin precursors has been developed.

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页码：6309 / 6312

页数：4

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