MULTISTAGE CARCINOGENESIS UTILIZING HUMAN GENITAL CELLS AND HUMAN PAPILLOMAVIRUSES

被引：4

作者：

DIPAOLO, JA

POPESCU, NC

ABLASHI, DV

LUSSO, P

ZIMONJIC, DB

WOODWORTH, CD

机构：

[1] National Cancer Institute, Laboratory of Biology, Bethesda

来源：

TOXICOLOGY LETTERS | 1994年 / 72卷 / 1-3期

关键词：

CERVICAL EPITHELIUM; COCARCINOGENESIS; SMOKING; HUMAN PAPILLOMAVIRUS; HUMAN HERPESVIRUS;

D O I：

10.1016/0378-4274(94)90004-3

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The preponderance of evidence indicates that a subset of human papillomaviruses are important etiological agents for cervical cancer. However, the necessity of other agents as well as cellular events is recognized because not all women with papillomaviruses develop cancer. Therefore, the exact role of papillomaviruses in the multistage carcinogenesis process is unclear. Regulation of specific viral genes is important to the malignant process. The current study demonstrates that human herpesvirus-6, another ubiquitous virus, can infect genital epithelial cells and upregulate the expression of relevant papillomavirus genes. Thus, it can be considered a cofactor for cancer.

引用

页码：7 / 11

页数：5

共 11 条

[1] HUMAN B-LYMPHOTROPIC VIRUS (HUMAN HERPESVIRUS-6) [J].

ABLASHI, DV ;

JOSEPHS, SF ;

BUCHBINDER, A ;

HELLMAN, K ;

NAKAMURA, S ;

LLANA, T ;

LUSSO, P ;

KAPLAN, M ;

DAHLBERG, J ;

MEMON, S ;

IMAM, F ;

ABLASHI, KL ;

MARKHAM, PD ;

KRAMARSKY, B ;

KRUEGER, GRF ;

BIBERFELD, P ;

WONGSTAAL, F ;

SALAHUDDIN, SZ ;

GALLO, RC .

JOURNAL OF VIROLOGICAL METHODS, 1988, 21 (1-4) :29-48

[2] CIGARETTE-SMOKING AND INVASIVE CERVICAL-CANCER [J].

BRINTON, LA ;

SCHAIRER, C ;

HAENSZEL, W ;

STOLLEY, P ;

LEHMAN, HF ;

LEVINE, R ;

SAVITZ, DA .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1986, 255 (23) :3265-3269

[3]

DIPAOLO J A, 1992, Proceedings of the American Association for Cancer Research Annual Meeting, V33, P392

[4]

DIPAOLO JA, 1993, CRIT REV ONCOGENESIS, V4, P337

[5] HUMAN HERPES VIRUS-6 INCREASES HIV-1 EXPRESSION IN CO-INFECTED T-CELLS VIA NUCLEAR FACTORS BINDING TO THE HIV-1 ENHANCER [J].

ENSOLI, B ;

LUSSO, P ;

SCHACHTER, F ;

JOSEPHS, SF ;

RAPPAPORT, J ;

NEGRO, F ;

GALLO, RC ;

WONGSTAAL, F .

EMBO JOURNAL, 1989, 8 (10) :3019-3027

[6] A LONG-TERM STUDY OF HEPATITIS-C VIRUS-REPLICATION IN NON-A, NON-B HEPATITIS [J].

FARCI, P ;

ALTER, HJ ;

WONG, D ;

MILLER, RH ;

SHIH, JW ;

JETT, B ;

PURCELL, RH .

NEW ENGLAND JOURNAL OF MEDICINE, 1991, 325 (02) :98-104

[7]

HAUSEN HZ, 1989, CANCER RES, V49, P4677

[8] HERPES-SIMPLEX VIRUS TYPE-2 - A POSSIBLE INTERACTION WITH HUMAN PAPILLOMAVIRUS TYPES-16/18 IN THE DEVELOPMENT OF INVASIVE CERVICAL-CANCER [J].

HILDESHEIM, A ;

MANN, V ;

BRINTON, LA ;

SZKLO, M ;

REEVES, WC ;

RAWLS, WE .

INTERNATIONAL JOURNAL OF CANCER, 1991, 49 (03) :335-340

[9] MOLECULAR STUDIES OF HHV-6 [J].

JOSEPHS, SF ;

ABLASHI, DV ;

SALAHUDDIN, SZ ;

KRAMARSKY, B ;

FRANZA, BR ;

PELLETT, P ;

BUCHBINDER, A ;

MEMON, S ;

WONGSTAAL, F ;

GALLO, RC .

JOURNAL OF VIROLOGICAL METHODS, 1988, 21 (1-4) :179-190

[10] RECENT PROGRESS IN DEFINING THE EPIDEMIOLOGY OF HUMAN PAPILLOMAVIRUS INFECTION AND CERVICAL NEOPLASIA [J].

SCHIFFMAN, MH .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1992, 84 (06) :394-398

← 1 2 →