SYNTHESIS OF POLY(GAMMA-BENZYL L-GLUTAMATE) POLY(ETHYLENE OXIDE) DIBLOCK COPOLYMER ENDCAPPED WITH SUGAR MOIETY FOR CELL-SPECIFIC BIOMATERIALS

被引：9
|
作者：
CHO, CS
CHUNG, SJ
GOTO, M
KOBAYASHI, A
AKAIKE, T
机构：
[1] CHONNAM NATL UNIV, DEPT POLYMER ENGN, KWANGJU 500757, SOUTH KOREA
[2] KANAGAWA ACAD SCI & TECHNOL, TAKATSU KU, KANAGAWA 213, JAPAN
[3] TOKYO INST TECHNOL, FAC BIOSCI & BIOTECHNOL, MIDORI KU, KANAGAWA 227, JAPAN
来源：
CHEMISTRY LETTERS | 1994年 / 10期
关键词：
D O I：
10.1246/cl.1994.1817
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
AB block copolymers consisting of poly(gamma-benzyl L-glutamate)(PBLG) as component A and poly(ethylene oxide) as component B were prepared containing [O-beta-D-galactopyranosyl-( 1 --> 4)]-D-gluconamide or [O-alpha-D-glucopyranosyl-(1 --> 4)]-D-gluconamide, From the circular dichroism measurements in solution state as well as infrared measurements in solid state, it was found that they had a-helical structure in both states as same as for the PBLG homopolymer. From adhesion of hepatocytes to the copolymer in vitro, it was found that lactose-carrying PBLG/PEO block copolymer had about 80% of adhesion within 2 h.
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页码：1817 / 1820
页数：4
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