MURINE BRAIN MACROPHAGES INDUCE NMDA RECEPTOR MEDIATED NEUROTOXICITY INVITRO BY SECRETING GLUTAMATE

被引：386

作者：

PIANI, D

FREI, K

DO, KQ

CUENOD, M

FONTANA, A

机构：

[1] UNIV HOSP ZURICH,DEPT INTERNAL MED,CLIN IMMUNOL SECT,HALDELIWEG 4,CH-8044 ZURICH,SWITZERLAND

[2] UNIV ZURICH,BRAIN RES INST,CH-8006 ZURICH,SWITZERLAND

来源：

NEUROSCIENCE LETTERS | 1991年 / 133卷 / 02期

关键词：

MACROPHAGE; MICROGLIAL CELL; ASTROCYTE; NEUROTOXICITY; EXCITATORY AMINO ACID; GLUTAMATE; NMDA RECEPTOR; GLIOSIS;

D O I：

10.1016/0304-3940(91)90559-C

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Supernatants (SN) of brain macrophages in culture induce death of cerebellar granule cells in vitro, while those of astrocytes and endothelial cells do not. This toxicity can be prevented by N-methyl-D-aspartate (NMDA) receptor antagonists. Macrophage SN contain high concentrations of glutamate. Reducing the glutamate level of macrophage SN, either by exposure to astrocytes or by enzymatic degradation abolished the toxic effect. Thus, macrophage neurotoxicity is mediated by glutamate acting on NMDA receptors, and might play a role in vivo in traumatic and cerebrovascular brain lesions.

引用

页码：159 / 162

页数：4

共 29 条

[1] ELEVATION OF THE EXTRACELLULAR CONCENTRATIONS OF GLUTAMATE AND ASPARTATE IN RAT HIPPOCAMPUS DURING TRANSIENT CEREBRAL-ISCHEMIA MONITORED BY INTRACEREBRAL MICRODIALYSIS [J].