A MULTIVARIATE MORPHOMETRIC ANALYSIS OF HIPPOCAMPAL ANATOMICAL VARIATION IN C57BL/6[--]BALB/C CHIMERIC MICE

被引：8

作者：

CRUSIO, WE ^{[1
]}

BAR, IM ^{[1
]}

SCHWEGLER, H ^{[1
]}

BUSELMAIER, W ^{[1
]}

机构：

[1] UNIV HEIDELBERG,INST HUMANGENET & ANTHROPOL,W-6900 HEIDELBERG,GERMANY

来源：

BRAIN RESEARCH | 1990年 / 535卷 / 02期

关键词：

CHIMERA; HIPPOCAMPAL ANATOMY; MORPHOMETRY; INBRED STRAIN; MOUSE;

D O I：

10.1016/0006-8993(90)91622-N

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated hippocampal anatomy in artifically-produced chimeras derived by the aggregation of embryos from two widely-studied inbred mouse strains, C57BL/6J and BALB/cJ. Contrary to expectations, the chimeras were not always intermediate between the parental strains. For a number of characters, the chimeras exceeded qualitatively as well as quantitatively the phenotypical range displayed by both inbred parental strains. These findings imply that if only one parent is available for comparison, for instance, in studies involving a normally inviable genotype, separating effects of this genotype from idiosyncratic effects inherent to the chimeric model will be very difficult, if not impossible.

引用

页码：343 / 346

页数：4

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