Effects of congenital heart disease on brain development

被引：115
作者：
McQuillen, Patrick S. [1 ]
Goff, Donna A. [2 ]
Licht, Daniel J. [3 ]
机构：
[1] Univ Calif San Francisco, Dept Pediat, Div Crit Care, San Francisco, CA 94143 USA
[2] Childrens Hosp Philadelphia, Dept Pediat, Div Cardiol, Philadelphia, PA 19104 USA
[3] Childrens Hosp Philadelphia, Div Neurol, Dept Pediat, Philadelphia, PA 19104 USA
来源：
PROGRESS IN PEDIATRIC CARDIOLOGY | 2010年 / 29卷 / 02期
关键词：
Congenital heart defects; Brain development; White matter injury; Periventricular leukomalacia; Infant heart surgery; Fetal circulation;
D O I：
10.1016/j.ppedcard.2010.06.011
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Brain and heart development occurs simultaneously in the fetus with congenital heart disease. Early morphogenetic programs in each organ share common genetic pathways. Brain development occurs across a more protracted time-course with striking brain growth and activity-dependent formation and refinement of connections in the third trimester. This development is associated with increased metabolic activity and the brain is dependent upon the heart for oxygen and nutrient delivery. Congenital heart disease leads to derangements of fetal blood flow that result in impaired brain growth and development that can be measured with advanced magnetic resonance imaging. Delayed development results in a unique vulnerability to cerebral white matter injury in newborns with congenital heart disease. Delayed brain development and acquired white matter injury may underlay mild but pervasive neurodevelopmental impairment commonly observed in children following neonatal congenital heart surgery. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：79 / 85
页数：7
相关论文
共 64 条
  • [1] Automated retrieval of standard diagnostic fetal cardiac ultrasound planes in the second trimester of pregnancy: a prospective evaluation of software
    Abuhamad, A.
    Falkensammer, P.
    Reichartseder, F.
    Zhao, Y.
    [J]. ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 2008, 31 (01) : 30 - 36
  • [2] Brain immaturity is associated with brain injury before and after neonatal cardiac surgery with high-flow bypass and cerebral oxygenation monitoring
    Andropoulos, Dean B.
    Hunter, Jill V.
    Nelson, David P.
    Stayer, Stephen A.
    Stark, Ann R.
    McKenzie, E. Dean
    Heinle, Jeffrey S.
    Graves, Daniel E.
    Fraser, Charles D., Jr.
    [J]. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2010, 139 (03) : 543 - 556
  • [3] NORMAL VALUES OF PULSATILITY INDEX FROM FETAL VESSELS - A CROSS-SECTIONAL STUDY ON 1556 HEALTHY FETUSES
    ARDUINI, D
    RIZZO, G
    [J]. JOURNAL OF PERINATAL MEDICINE, 1990, 18 (03) : 165 - 172
  • [4] Artman M, 2002, NEONATAL CARDIOLOGY, P39
  • [5] Back SA, 2001, J NEUROSCI, V21, P1302
  • [6] Maturation-dependent vulnerability of perinatal white matter in premature birth
    Back, Stephen A.
    Riddle, Art
    McClure, Melissa M.
    [J]. STROKE, 2007, 38 (02) : 724 - 730
  • [7] Protective effects of caffeine on chronic hypoxia-induced perinatal white matter injury
    Back, Stephen A.
    Craig, Andrew
    Luo, Ning Ling
    Ren, Jennifer
    Akundi, Ravi Shankar
    Ribeiro, Ivy
    Rivkees, Scott A.
    [J]. ANNALS OF NEUROLOGY, 2006, 60 (06) : 696 - 705
  • [8] Identification of pressure passive cerebral perfusion and its mediators after infant cardiac surgery
    Bassan, H
    Gauvreau, K
    Newburger, JW
    Tsuji, M
    Limperopoulos, C
    Soul, JS
    Walter, G
    Laussen, PC
    Jonas, RA
    Du Plessis, AJ
    [J]. PEDIATRIC RESEARCH, 2005, 57 (01) : 35 - 41
  • [9] A molecular neuroanatomical study of the developing human neocortex from 8 to 17 postconceptional weeks revealing the early differentiation of the subplate and subventricular zone
    Bayatti, Nadhim
    Moss, Jennifer A.
    Sun, Li
    Ambrose, Philip
    Ward, Joseph F. H.
    Lindsay, Susan
    Clowry, Gavin J.
    [J]. CEREBRAL CORTEX, 2008, 18 (07) : 1536 - 1548
  • [10] Childs AM, 2001, AM J NEURORADIOL, V22, P1577
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