PRIMARY NEUROGENESIS IN XENOPUS EMBRYOS REGULATED BY A HOMOLOG OF THE DROSOPHILA NEUROGENIC GENE-DELTA

被引：623

作者：

CHITNIS, A ^{[1
]}

HENRIQUE, D ^{[1
]}

LEWIS, J ^{[1
]}

ISHHOROWICZ, D ^{[1
]}

KINTNER, C ^{[1
]}

机构：

[1] UNIV OXFORD, DEPT ZOOL,IMPERIAL CANC RES FUND, DEV GENET & ORGANOGENESIS LABS,DEV BIOL UNIT, OXFORD OX1 3PS, ENGLAND

来源：

NATURE | 1995年 / 375卷 / 6534期

关键词：

D O I：

10.1038/375761a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

X-Delta-1, a Xenopus homologue of the Drosophila Delta gene, is expressed in the early embryonic nervous system in scattered cells that appear to be the prospective primary neurons. Ectopic X-Delta-1 activity inhibits production of primary neurons and interference with endogenous X-Delta-1 activity results in overproduction of primary neurons. These results indicate that the X-Delta-1 protein mediates lateral inhibition delivered by prospective neurons to adjacent cells, and that commitment to a neural fate in vertebrates is regulated by Delta-Notch signalling as in Drosophila.

引用

页码：761 / 766

页数：6

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