THE EFFECT OF DIETARY FIBER ON APOLIPOPROTEIN-A-I AND A-IV GENE-EXPRESSION IN RAT INTESTINE

The effect of the dietary fiber on apo A-1 and apo A-IV mRNA levels was studied in the intestine of rats fed either by fiber-free or high-fiber diets. Rats fed high-fiber diet had lower plasma cholesterol concentrations than animals fed fiber-free diet. A proximal-distal apo A-I and apo A-IV mRNA gradient was found in both groups. High-fiber diet feeding reduced apo A-I mRNA levels in jejunum and ileum and ileal apo A-IV mRNA levels as compared to fiber-free diet fed rats. The obtained results suggest that some dietary fibers may play a role in regulation of lipoprotein metabolism in the intestine, including apolipoprotein synthesis.