USE OF ATR-FTIR SPECTROSCOPY TO STUDY THE DIFFUSION OF ETHANOL THROUGH GLYCEROGELATIN FILMS

被引：13
|
作者：
MARGARIDA, A
TRALHAO, L
WATKINSON, AC
BRAIN, KR
HADGRAFT, J
ARMSTRONG, NA
机构：
[1] ANEX,CARDIFF CF1 3XF,S GLAM,WALES
[2] UNIV WALES COLL CARDIFF,WELSH SCH PHARM,CARDIFF CF1 3XF,S GLAM,WALES
来源：
PHARMACEUTICAL RESEARCH | 1995年 / 12卷 / 04期
关键词：
ATR-FTIR; DEUTERATION; DIFFUSION COEFFICIENT; ETHANOL; GLYCEROGELATIN FILMS; SOFT GELATIN CAPSULES;
D O I：
10.1023/A:1016262215192
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The use of ATR-FTIR spectroscopy to study the permeability of a glycerogelatin film is described. Measurement of the diffusion coefficient of ethyl alcohol-d in the film showed excellent reproducibility. Comparison of results from this technique with those previously obtained using an air-flow receptor phase diffusion cell show good agreement in terms of lag time assessed diffusion coefficients. ATR-FTIR spectroscopy revealed time-dependent changes in the composition of the glycerogelatin film during the diffusional process. It was also demonstrated that the concurrent assessment of both diffusant penetration and film composition is feasible.
引用
收藏
页码：572 / 575
页数：4
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