LIPOPOLYSACCHARIDE-INDUCED IGM PRODUCTION IS NOT SUPPRESSED BY ANTIGEN RECEPTOR LIGATION IN B-CELLS FROM SOME AUTOIMMUNE STRAINS OF MICE

被引：3

作者：

ANDERSON, CC ^{[1
]}

RAHIMPOUR, R ^{[1
]}

SINCLAIR, NRS ^{[1
]}

机构：

[1] UNIV WESTERN ONTARIO,DEPT MICROBIOL & IMMUNOL,LONDON,ON N6A 5C1,CANADA

来源：

IMMUNOLOGIC RESEARCH | 1994年 / 13卷 / 01期

关键词：

ANTAGONISM; ANTIBODY PRODUCTION; ANTIGEN RECEPTOR; AUTOIMMUNITY; B CELL DIFFERENTIATION; LIPOPOLYSACCHARIDE; IGM PRODUCTION; POLYCLONAL B CELL ACTIVATION; SURFACE IMMUNOGLOBULIN;

D O I：

10.1007/BF02918220

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ligation of surface immunoglobulin on resting or activated nonautoimmune B cells inhibited lipopolysaccharide (LPS)induced total IgM production. B cells from NZB, (NZB x NZW)FI, and BXSB mice were relatively resistant, but B cells from NZW or MRL/lpr mice were inhibited. The resistance occurs in B cells from young and old NZB mice, and in both resting and activated splenic NZB B cells. Anti-ssDNA responses induced by lipopolysaccharide occur in the presence of antigen-receptor-ligating antibody in NZB, but not in DBA/2, B cells. Antagonism in signaling between the antigen and LPS receptor is not a general B cell hyporesponsiveness, but defects in antagonism specifically between antigen and LPS signaling may be a predisposing factor to autoimmune disease in some autoimmune strains of mice.

引用

页码：10 / 20

页数：11

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