LITHIUM EFFECTS ON ESTROGEN-INDUCED DOPAMINERGIC SUPERSENSITIVITY IN RATS

被引：0
作者：
DORCE, VAC [1 ]
PALERMONETO, J [1 ]
机构：
[1] UNIV SAO PAULO,SCH VET MED,APPL PHARMACOL & TOXICOL LAB,SAO PAULO,BRAZIL
来源：
BRAIN RESEARCH BULLETIN | 1992年 / 29卷 / 02期
关键词：
LITHIUM; ESTROGEN; DOPAMINE; SUPERSENSITIVITY; STEREOTYPED BEHAVIOR;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effect of lithium (2.0 mEq/kg, IP) on dopaminergic supersensitivity induced by longterm estrogen treatment (0.25 mg/day, SC) was investigated. Ovariectomized rats were treated for 28 days with estrogen and/or lithium and 6 days after the last administration all animals were observed for apomorphine-induced stereotyped behavior (1.0 mg/kg, SC). The abrupt withdrawal from long-term estrogen treatment increased rats' sensitivity to apomorphine but lithium administration was able to prevent this increase. Lithium alone produced no effect on stereotyped behavior. It was suggested that lithium may antagonize the estrogen effect on the nigrostriatal dopamine system.
引用
收藏
页码：239 / 241
页数：3
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