LITHIUM EFFECTS ON ESTROGEN-INDUCED DOPAMINERGIC SUPERSENSITIVITY IN RATS

被引：0

作者：

DORCE, VAC ^{[1
]}

PALERMONETO, J ^{[1
]}

机构：

[1] UNIV SAO PAULO,SCH VET MED,APPL PHARMACOL & TOXICOL LAB,SAO PAULO,BRAZIL

来源：

BRAIN RESEARCH BULLETIN | 1992年 / 29卷 / 02期

关键词：

LITHIUM; ESTROGEN; DOPAMINE; SUPERSENSITIVITY; STEREOTYPED BEHAVIOR;

D O I：

暂无

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of lithium (2.0 mEq/kg, IP) on dopaminergic supersensitivity induced by longterm estrogen treatment (0.25 mg/day, SC) was investigated. Ovariectomized rats were treated for 28 days with estrogen and/or lithium and 6 days after the last administration all animals were observed for apomorphine-induced stereotyped behavior (1.0 mg/kg, SC). The abrupt withdrawal from long-term estrogen treatment increased rats' sensitivity to apomorphine but lithium administration was able to prevent this increase. Lithium alone produced no effect on stereotyped behavior. It was suggested that lithium may antagonize the estrogen effect on the nigrostriatal dopamine system.

引用

页码：239 / 241

页数：3

共 41 条

[11] INTERMITTENT INFUSION OF PROGESTERONE POTENTIATES WHEREAS CONTINUOUS INFUSION REDUCES AMPHETAMINE-STIMULATED DOPAMINE RELEASE FROM OVARIECTOMIZED ESTROGEN-PRIMED RAT STRIATAL FRAGMENTS SUPERFUSED INVITRO
DLUZEN, DE
RAMIREZ, VD
[J]. BRAIN RESEARCH, 1987, 406 (1-2) : 1 - 9
[12] DORCE VAC, 1988, BRAZ J MED BIOL RES, V21, P313
[13] REGIONAL EFFECT OF ESTRADIOL ON RAT CAUDATE-PUTAMEN DOPAMINE-RECEPTORS - LATERAL MEDIAL DIFFERENCES
FALARDEAU, P
DIPAOLO, T
[J]. NEUROSCIENCE LETTERS, 1987, 74 (01) : 43 - 48
[14] TIME-DEPENDENT EFFECTS OF ESTRADIOL AND PROGESTERONE ON THE NUMBER OF STRIATAL DOPAMINERGIC D2-RECEPTORS
FERNANDEZRUIZ, JJ
AMOR, JC
RAMOS, JA
[J]. BRAIN RESEARCH, 1989, 476 (02) : 388 - 395
[15] FLEMING WW, 1975, J PHARMACOL EXP THER, V192, P381
[16] PRE-SYNAPTIC AND POSTSYNAPTIC NEUROCHEMICAL ALTERATIONS FOLLOWING ESTROGEN-INDUCED STRIATAL DOPAMINE HYPOSENSITIVITY AND HYPERSENSITIVITY
GORDON, JH
PERRY, KO
[J]. BRAIN RESEARCH BULLETIN, 1983, 10 (04) : 425 - 428
[17] BIOCHEMICAL AND FUNCTIONAL ALTERATIONS OF CENTRAL GABA RECEPTORS DURING CHRONIC ESTRADIOL TREATMENT
HAMON, M
GOETZ, C
EUVRARD, C
PASQUALINI, C
LEDAFNIET, M
KERDELHUE, B
CESSELIN, F
PEILLON, F
[J]. BRAIN RESEARCH, 1983, 279 (1-2) : 141 - 152
[18] CHARACTERIZATION OF THE STRIATAL DOPAMINE RECEPTOR SUPER-SENSITIVITY PRODUCED BY ESTROGEN-TREATMENT OF MALE-RATS
HRUSKA, RE
LUDMER, LM
SILBERGELD, EK
[J]. NEUROPHARMACOLOGY, 1980, 19 (09) : 923 - 926
[19] ESTROGEN-TREATMENT INCREASES THE ORAL COMPONENT OF APOMORPHINE-INDUCED STEREOTYPY
JOHNSON, NJ
STEVENS, R
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 100 (02) : 181 - 188
[20] RAPID CONVERSION OF HIGH INTO LOW STRIATAL D2-DOPAMINE RECEPTOR AGONIST BINDING STATES AFTER AN ACUTE PHYSIOLOGICAL DOSE OF 17-BETA-ESTRADIOL
LEVESQUE, D
DIPAOLO, T
[J]. NEUROSCIENCE LETTERS, 1988, 88 (01) : 113 - 118

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