DETERMINATION OF RELIABLE REGIONS IN PROTEIN-SEQUENCE ALIGNMENTS

被引：82
作者：
VINGRON, M
ARGOS, P
机构：
[1] European Molecular Biology Laboratory, Meyerhofstrasse 1, 6900 Heidelberg, Postfach 10
来源：
PROTEIN ENGINEERING | 1990年 / 3卷 / 07期
关键词：
Alignment reliability; Alignment significance; Sequence alignment;
D O I：
10.1093/protein/3.7.565
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Judging the significance of alignments is still a major problem in sequence comparison. We present a method to delineate reliable regions within an alignment. This differs from standard approaches in that it does not attempt to attribute one significance value to the alignment as a whole, but assesses alignment quality locally. An algorithm is provided that predicts which residue pairs in an alignment are likely to be correctly matched. The predictions are evaluated by comparison with alignments taken from tertiary structural superpositions. © 1990 Oxford University Press.
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页码：565 / 569
页数：5
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