AKR1C3 inhibition therapy in castration-resistant prostate cancer and breast cancer: lessons from responses to SN33638

被引:6
作者
Zhou, Wen [1 ]
Limonta, Patrizia [2 ]
机构
[1] Univ Miami, Miller Sch Med, Sylvester Comprehens Canc Ctr, Braman Family Breast Canc Inst, Miami, FL 33136 USA
[2] Univ Milan, Dept Pharmacol & Biomol Sci, Milan, Italy
来源
FRONTIERS IN ONCOLOGY | 2014年 / 4卷
关键词
AKR1C3; SN33638; castration-resistant prostate cancer; breast cancer; testosterone; 17; beta-estradiol;
D O I
10.3389/fonc.2014.00162
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页数:2
相关论文
共 6 条
  • [1] The development of androgen-independent prostate cancer
    Feldman, BJ
    Feldman, D
    [J]. NATURE REVIEWS CANCER, 2001, 1 (01) : 34 - 45
  • [2] Synthesis and structure-activity relationships for 1-(4-(piperidin-1-ylsulfonyl)phenyl)pyrrolidin-2-ones as novel non-carboxylate inhibitors of the aldo-keto reductase enzyme AKR1C3
    Heinrich, Daniel M.
    Flanagan, Jack U.
    Jamieson, Stephen M. F.
    Silva, Shevan
    Rigoreau, Laurent J. M.
    Trivier, Elisabeth
    Raynham, Tony
    Turnbull, Andrew P.
    Denny, William A.
    [J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 62 : 738 - 744
  • [3] Maintenance of intratumoral androgens in metastatic prostate cancer: A mechanism for castration-resistant tumor growth
    Montgomery, R. Bruce
    Mostaghel, Elahe A.
    Vessella, Robert
    Hess, David L.
    Kalhorn, Thomas F.
    Higano, Celestia S.
    True, Lawrence D.
    Nelson, Peter S.
    [J]. CANCER RESEARCH, 2008, 68 (11) : 4447 - 4454
  • [4] In situ estrogen production and its regulation in human breast carcinoma: From endocrinology to intracrinology
    Sasano, Hironobu
    Miki, Yasuhiro
    Nagasaki, Shuji
    Suzuki, Takashi
    [J]. PATHOLOGY INTERNATIONAL, 2009, 59 (11) : 777 - 789
  • [5] The activity of SN33638, an inhibitor of AKR1C3, on testosterone and 17 beta-estradiol production and function in castration-resistant prostate cancer and ER-positive breast cancer
    Yin, Yarong Diana
    Fu, Melissa
    Brooke, Darby G.
    Heinrich, Daniel M.
    Denny, William A.
    Jamieson, Stephen M. F.
    [J]. FRONTIERS IN ONCOLOGY, 2014, 4
  • [6] Links between oestrogen receptor activation and proteolysis: relevance to hormone-regulated cancer therapy
    Zhou, Wen
    Slingerland, Joyce M.
    [J]. NATURE REVIEWS CANCER, 2014, 14 (01) : 26 - 38