CHANGES IN NEUROGLIA AND MYELINATION IN WHITE MATTER OF AGING MICE

被引：59

作者：

STURROCK, RR ^{[1
]}

机构：

[1] UNIV DUNDEE, DUNDEE DD1 4HN, SCOTLAND

来源：

JOURNALS OF GERONTOLOGY | 1976年 / 31卷 / 05期

关键词：

D O I：

10.1093/geronj/31.5.513

中图分类号：

R4 [临床医学]; R592 [老年病学];

学科分类号：

1002 ; 100203 ; 100602 ;

摘要：

Changes with age were investigated in the anterior and posterior limbs of the anterior commissure of the brains of 5 mo. old and 18 mo. old mice. In the 18 mo. old animals the total number of glia was reduced by 40% in both limbs. All types of glia were reduced in numbers, the astrocytes being most affected. Ultrastructural changes were also most obvious in astrocytes. There was no significant change in the number of axons, percentage myelination, axonal diameter (myelinated or unmyelinated) nor in the mean number of myelin lamellae in either limb in the 18 mo. old animals. The percentage of redundant myelin sheaths increased significantly in 18 mo. old animals.

引用

页码：513 / 522

页数：10

共 34 条

[1] ESTIMATION OF NUCLEAR POPULATION FROM MICROTOME SECTIONS [J].