COLOCALIZATION OF FOS- AND GLUCOCORTICOID RECEPTOR-IMMUNOREACTIVITIES IS PRESENT ONLY IN A VERY RESTRICTED POPULATION OF DORSAL HORN NEURONS OF THE RAT SPINAL-CORD AFTER NOCICEPTIVE STIMULATION

被引：29

作者：

CINTRA, A

MOLANDER, C

FUXE, K

机构：

[1] Department of Neuroscience, Karolinska Institute, S-171 77 Stockholm

来源：

BRAIN RESEARCH | 1993年 / 632卷 / 1-2期

关键词：

GLUCOCORTICOID RECEPTOR; CORTICOSTEROID; PAIN; IMMUNOCYTOCHEMISTRY; IMMEDIATE EARLY GENE; C-FIBER STIMULATION; NOCICEPTION; PRIMARY SENSORY NEURON;

D O I：

10.1016/0006-8993(93)91172-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Immunocytochemical techniques were used to study the colocalization of proto-oncogene c-fos protein (Fos)-like immunoreactivity and of glucocorticoid receptor immunoreactivity in the spinal cord dorsal horn of adult male rats after nociceptive stimulation. About 5-10% of the stimulus evoked Fos-immunoreactive profiles colocalized glucocorticoid receptor immunoreactivity. The results suggest the possibility of a corticosteroid action in a small neuronal population of the dorsal horn implicated in processing nociceptive inputs.

引用

页码：334 / 338

页数：5

共 6 条

[1] BENZODIAZEPINES AND PAIN - EFFECTS OF MIDAZOLAM ON THE ACTIVITIES OF NOCICEPTIVE NONSPECIFIC DORSAL HORN NEURONS IN THE RAT SPINAL-CORD
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LOMBARD, MC
BESSON, JM
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[2] NEURONS IN THE SUPERFICIAL DORSAL HORN OF THE RAT SPINAL-CORD PROJECTING TO THE MEDULLARY VENTROLATERAL RETICULAR-FORMATION EXPRESS C-FOS AFTER NOXIOUS-STIMULATION OF THE SKIN
TAVARES, I
LIMA, D
COIMBRA, A
BRAIN RESEARCH, 1993, 623 (02) : 278 - 286
[3] EXPRESSION OF NITRIC-OXIDE SYNTHASE AND COLOCALIZATION WITH JUN, FOS AND KROX TRANSCRIPTION FACTORS IN SPINAL-CORD NEURONS FOLLOWING NOXIOUS-STIMULATION OF THE RAT HINDPAW
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RUDIGER, S
MAYER, B
BRAVO, R
ZIMMERMANN, M
MOLECULAR BRAIN RESEARCH, 1994, 22 (1-4): : 245 - 258
[4] Effect of morphine on cholecystokinin and μ-opioid receptor-like immunoreactivities in rat spinal dorsal horn neurons after peripheral axotomy and inflammation
Zhang, X
Lucas, GD
Elde, R
Wiesenfeld-Hallin, Z
Hökfelt, T
NEUROSCIENCE, 2000, 95 (01) : 197 - 207
[5] The mu-opioid receptor (MOR1) is mainly restricted to neurons that do not contain GABA or glycine in the superficial dorsal horn of the rat spinal cord
Kemp, T
Spike, RC
Watt, C
Todd, AJ
NEUROSCIENCE, 1996, 75 (04) : 1231 - 1238
[6] 7-NITRO-INDAZOLE, A SELECTIVE INHIBITOR OF NEURONAL NITRIC-OXIDE SYNTHASE, REDUCES FORMALIN EVOKED C-FOS EXPRESSION IN DORSAL HORN NEURONS OF THE RAT SPINAL-CORD
CHAPMAN, V
BURITOVA, J
HONORE, P
BESSON, JM
BRAIN RESEARCH, 1995, 697 (1-2) : 258 - 261

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