COLOCALIZATION OF FOS- AND GLUCOCORTICOID RECEPTOR-IMMUNOREACTIVITIES IS PRESENT ONLY IN A VERY RESTRICTED POPULATION OF DORSAL HORN NEURONS OF THE RAT SPINAL-CORD AFTER NOCICEPTIVE STIMULATION

被引：29
作者：
CINTRA, A
MOLANDER, C
FUXE, K
机构：
[1] Department of Neuroscience, Karolinska Institute, S-171 77 Stockholm
来源：
BRAIN RESEARCH | 1993年 / 632卷 / 1-2期
关键词：
GLUCOCORTICOID RECEPTOR; CORTICOSTEROID; PAIN; IMMUNOCYTOCHEMISTRY; IMMEDIATE EARLY GENE; C-FIBER STIMULATION; NOCICEPTION; PRIMARY SENSORY NEURON;
D O I：
10.1016/0006-8993(93)91172-O
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Immunocytochemical techniques were used to study the colocalization of proto-oncogene c-fos protein (Fos)-like immunoreactivity and of glucocorticoid receptor immunoreactivity in the spinal cord dorsal horn of adult male rats after nociceptive stimulation. About 5-10% of the stimulus evoked Fos-immunoreactive profiles colocalized glucocorticoid receptor immunoreactivity. The results suggest the possibility of a corticosteroid action in a small neuronal population of the dorsal horn implicated in processing nociceptive inputs.
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收藏
页码：334 / 338
页数：5
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