Pharmacologic and Nonpharmacologic Treatment of Restless Legs Syndrome

This article provides an updated practical guide for the treatment of primary restless legs syndrome (RLS). Articles that appeared after the American Academy of Neurology guideline search were reviewed according to the same evidence rating schedule. We found limited evidence for nonpharmacologic treatment options. In moderate to severe primary RLS, pharmacologic options may be considered, including iron supplementation, an alpha 2 delta ligand, a dopamine agonist, a combination of an alpha 2 delta ligand and a dopamine agonist, or oxycodone/naloxone. This article includes treatment options in case of augmentation.