An uneventful pregnancy and delivery, in a case with chronic myeloid leukemia on imatinib

被引：8

作者：

Martin, Jovita ^{[1
]}

Ramesh, Anita ^{[1
]}

Devadasan, Lalitha ^{[2
]}

Palaniappan ^{[2
]}

Martin, Jude J. ^{[2
]}

机构：

[1] Sri Ramachandra Med Coll & Hosp, Sri Ramachandra Med Coll, Dept Oncol, Porur, Tamil Nadu, India

[2] Trinity & Co, Dept Obstet & Gynaecol, Madras, Tamil Nadu, India

来源：

INDIAN JOURNAL OF MEDICAL AND PAEDIATRIC ONCOLOGY | 2011年 / 32卷 / 02期

关键词：

CML in pregnancy; imatinib in pregnancy; safety of imatinib in pregnancy;

D O I：

10.4103/0971-5851.89795

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The concomitant occurrence of pregnancy and chronic myelogenous leukemia is uncommon. We describe the successful management of a 24-year-old woman in the first trimester of her pregnancy with chronic myelogenous leukemia (CML) in the chronic phase, who was on treatment with imatinib, which was stopped by 10th week of pregnancy. Until, she completed full term of pregnancy she was on hydroxyurea. The use of imatinib did not have adverse effects on the fetus. The patient had a normal vaginal delivery and gave birth to a healthy 2500 g girl at 37 weeks of gestation. We conclude that imatinib in the first trimester of pregnant lady with CML, though has particular concern regarding the potential teratogenic and other adverse effects, has shown evidences of safe conception, pregnancy and delivery in ladies with CML.

引用

页码：109 / 111

页数：3