SCREENING OF ANTI-INFLAMMATORY AND ANTI ANALGESIC ACTIVITY OF CONVOLVULUS PLURICAULIS CHOISY

Objective: This study was designed for Screening of anti-inflammatory and anti-analgesic activity of ethanolic extract of Convolvulus pluricaulis Choisy in various animal experimental models. Material and Methods: Ethanolic extract of Convolvulus pluricaulis Choisy evaluated for anti-inflammatory activity in Carrageenaninduced paw edema, Cotton pellet-induced granuloma model. The anti-analgesic activity was evaluated by Hot Plate Method and TailFlick Assay. Result: Administration of the ethanolic extract of Convolvulus pluricaulis Choisy at dose of 800 mg/kg p.o. showed significant (P < 0.001) inhibition of rat paw edema. The analgesic activity was determined on Wistar albino rats by hot plate method, tail flick assay using Morphine sulphate as standard drug at a dose of 5 mg/kg of body weight and the results were expressed as mean increase in latency after drug administration +/- SEM. Conclusion: This study shows that ethanolic extract of Convolvulus pluricaulis Choisy has significant anti-inflammatory and antianalgesic activity.