ANALYSIS OF NON-BENZODIAZEPINIC ANXIOLYTIC AGENTS BY CAPILLARY ZONE ELECTROPHORESIS

被引：8
作者：
QUAGLIA, MG
FARINA, A
BOSSU, E
DELLAQUILA, C
机构：
[1] IST SUPER SANITA,CHIM FARMACO LAB,I-00161 ROME,ITALY
[2] UNIV ROMA LA SAPIENZA,CNR,CTR STUDIO CHIM FARMACO,I-00185 ROME,ITALY
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1995年 / 13卷 / 4-5期
关键词：
ZALOSPIRONE; GEPIRONE; IPSAPIRONE; BUSPIRONE; RELATED IMPURITIES; CAPILLARY ZONE ELECTROPHORESIS; ANXIOLYTIC AGENT;
D O I：
10.1016/0731-7085(95)01340-Q
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A simple capillary electrophoretic method was developed for the analysis of a new generation of serotonergic anxiolytics and their related substances: zalospirone, gepirone, ipsapirone and buspirone. All compounds run in a Tris/phosphate buffer at pH 3 as cations and the experimental conditions allowed good resolution of four drugs and their principal impurities. The analyses were made rising two different kinds of capillary. The suitability of CZE and HPLC methods for the analysis of these non-benzodiazepinic anxiolytic agents and their impurities was compared.
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页码：505 / 509
页数：5
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