A RECOMBINANT HUMAN INTERLEUKIN-1-BETA PROTECTS ADRIAMYCIN-INDUCED TOXICITY - ADRIAMYCIN CARDIOTOXICITY AND INTERLEUKIN-1

被引：0

作者：

OKUMURA, H ^{[1
]}

YOSHIDA, T ^{[1
]}

KAYA, H ^{[1
]}

MATANO, S ^{[1
]}

OKABE, Y ^{[1
]}

OHTAKE, S ^{[1
]}

NAKAMURA, S ^{[1
]}

MATSUDA, T ^{[1
]}

机构：

[1] KANAZAWA UNIV,SCH MED,DEPT INTERNAL MED 3,KANAZAWA,ISHIKAWA,JAPAN

来源：

BIOTHERAPY | 1994年 / 7卷 / 02期

关键词：

INTERLEUKIN-1; ADRIAMYCIN; CHEMOPROTECTION; SUPEROXIDE;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pretreatment with recombinant human interleukin-1 beta (IL-I) protected normal BALB/c mice from the lethal effect adriamycin (ADM) of related to dose and frequency of administration. Posttreatment with IL-1 failed to protect. Neutrophil and platelet counts after the administration of ADM (16mg/kg) did not differ between the group with and that without IL-1 pretreatment, whereas lipid peroxide levels in the heart were reduced in the group pretreated with IL-1. It appears that the chemoprotection mechanism of IL-1 lies in the prevention of cardiotoxicity due to ADM-induced free radicals.

引用

页码：137 / 143

页数：7

共 29 条

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