GLUTATHIONE PEROXIDASE-LIKE ACTIVITY OF DIARYL TELLURIDES

被引：76
作者：
ANDERSSON, CM
HALLBERG, A
BRATTSAND, R
COTGREAVE, IA
ENGMAN, L
PERSSON, J
机构：
[1] ASTRA DRACO AB,DEPT PHARMACOL 1,S-22100 LUND,SWEDEN
[2] ASTRA DRACO AB,PRECLIN RES & DEV,S-22100 LUND,SWEDEN
[3] KAROLINSKA INST,DEPT TOXICOL,S-10401 STOCKHOLM 60,SWEDEN
[4] ROYAL INST TECHNOL,DEPT ORGAN CHEM,S-10044 STOCKHOLM 70,SWEDEN
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 12期
关键词：
D O I：
10.1016/S0960-894X(01)80715-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
4,4'-Disubstituted diaryl tellurides showed glutathione peroxidase-like catalysis of the reduction of hydroperoxides by glutathione. The most potent compound, bis(4-aminophenyl) telluride, demonstrated 348%, 530%, 995% and 900% of the catalytic efficacy of Ebselen for the glutathione dependent reduction of H2O2, t-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide, respectively.
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页码：2553 / 2558
页数：6
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