BASIC FIBROBLAST GROWTH-FACTOR BINDS TO FILAMENTOUS INCLUSIONS OF NEURODEGENERATIVE DISEASES

被引：34
作者：
PERRY, G
RICHEY, P
SIEDLAK, SL
GALLOWAY, P
KAWAI, M
CRAS, P
机构：
[1] Division of Neuropathology, Institute of Pathology, Case Western Reserve University, Cleveland
来源：
BRAIN RESEARCH | 1992年 / 579卷 / 02期
关键词：
ALZHEIMER DISEASE; HEPARAN SULFATE PROTEOGLYCAN; PICK DISEASE; PARKINSON DISEASE; PROGRESSIVE SUPRANUCLEAR PALSY; DIFFUSE LEWY BODY DISEASE;
D O I：
10.1016/0006-8993(92)90074-J
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The extracellular matrix protein heparan sulfate proteoglycans (HSPG) has been found in the neurofibrillary pathology of Alzheimer disease. This study was performed to determine if similar proteoglycans might be present in the fibrillary inclusions of other neurodegenerative diseases. Basic fibroblast growth factor (bFGF) binding to heparinase sensitive sites was used as an assay for HSPGs. We found that the inclusions of Pick and Parkinson diseases as well as progressive supranuclear palsy contained heparinase sensitive bFGF binding sites while the inclusions of diffuse Lewy body disease lacked bFGF binding sites. These findings indicate that HSPG's interactions and possible role in the formation of intraneuronal inclusions are not limited to Alzheimer disease.
引用
收藏
页码：350 / 352
页数：3
相关论文
共 16 条
[1]  
GALLOWAY PG, 1992, AM J PATHOL, V140, P809
[2]   TROPOMYOSIN DISTINGUISHES LEWY BODIES OF PARKINSON DISEASE FROM OTHER NEUROFIBRILLARY PATHOLOGY [J].
GALLOWAY, PG ;
PERRY, G .
BRAIN RESEARCH, 1991, 541 (02) :347-349
[3]   THE PRESENCE OF TAU DISTINGUISHES LEWY BODIES OF DIFFUSE LEWY BODY DISEASE FROM THOSE OF IDIOPATHIC PARKINSON DISEASE [J].
GALLOWAY, PG ;
BERGERON, C ;
PERRY, G .
NEUROSCIENCE LETTERS, 1989, 100 (1-3) :6-10
[4]   A PREPARATION OF ALZHEIMER PAIRED HELICAL FILAMENTS THAT DISPLAYS DISTINCT TAU-PROTEINS BY POLYACRYLAMIDE-GEL ELECTROPHORESIS [J].
GREENBERG, SG ;
DAVIES, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (15) :5827-5831
[5]   THE POTENTIAL SIGNIFICANCE OF SULFATED GLYCOSAMINOGLYCANS AS A COMMON CONSTITUENT OF ALL AMYLOIDS - OR, PERHAPS AMYLOID IS NOT A MISNOMER [J].
KISILEVSKY, R ;
SNOW, A .
MEDICAL HYPOTHESES, 1988, 26 (04) :231-236
[6]   A68 - A MAJOR SUBUNIT OF PAIRED HELICAL FILAMENTS AND DERIVATIZED FORMS OF NORMAL-TAU [J].
LEE, VMY ;
BALIN, BJ ;
OTVOS, L ;
TROJANOWSKI, JQ .
SCIENCE, 1991, 251 (4994) :675-678
[7]   UBIQUITIN IS ASSOCIATED WITH ABNORMAL CYTOPLASMIC FILAMENTS CHARACTERISTIC OF NEURODEGENERATIVE DISEASES [J].
MANETTO, V ;
PERRY, G ;
TABATON, M ;
MULVIHILL, P ;
FRIED, VA ;
SMITH, HT ;
GAMBETTI, P ;
AUTILIOGAMBETTI, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (12) :4501-4505
[8]  
PERRY G, 1991, J NEUROSCI, V11, P3679
[9]   PAIRED HELICAL FILAMENTS FROM ALZHEIMER-DISEASE PATIENTS CONTAIN CYTOSKELETAL COMPONENTS [J].
PERRY, G ;
RIZZUTO, N ;
AUTILIOGAMBETTI, L ;
GAMBETTI, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (11) :3916-3920
[10]  
PERRY G, 1991, J NEUROSCI, V11, P1748
12