CLINICAL CORRELATES OF WHITE-MATTER CHANGES ON MAGNETIC-RESONANCE-IMAGING SCANS OF THE BRAIN

被引：180
作者：
MIRSEN, TR
LEE, DH
WONG, CJ
DIAZ, JF
FOX, AJ
HACHINSKI, VC
MERSKEY, H
机构：
[1] JOHN P ROBARTS RES INST, CLIN TRIALS RESOURCES, LONDON, ONTARIO, CANADA
[2] UNIV WESTERN ONTARIO, DEPT CLIN NEUROL SCI, LONDON N6A 3K7, ONTARIO, CANADA
[3] UNIV WESTERN ONTARIO, DEPT PSYCHIAT, LONDON N6A 3K7, ONTARIO, CANADA
[4] UNIV WESTERN ONTARIO, DEPT RADIOL, LONDON N6A 3K7, ONTARIO, CANADA
来源：
ARCHIVES OF NEUROLOGY | 1991年 / 48卷 / 10期
关键词：
D O I：
10.1001/archneur.1991.00530220031015
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
We report our observations on the clinical and radiologic correlates of changes in cerebral white matter based on 94 subjects undergoing magnetic resonance imaging in a prospective study of dementia. Periventricular hyperintensity occurred twice as often in patients with Alzheimer's disease as in healthy control subjects. Within the control group, the presence of periventricular hyperintensity correlated significantly with one measure of cerebral atrophy and with the presence of changes in the adjoining deep white matter. The significance of white-matter changes distinct from the ventricles (leuko-araiosis) remains unsettled. Leukoaraiosis on the magnetic resonance imaging scan, unlike its correlate on the computed tomographic scan, was not shown to relate to cognitive decline or to the presence of focal abnormalities on neurologic examination. This is likely to reflect the heterogeneity of the changes detected with magnetic resonance imaging and their limited extent in our subjects.
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页码：1015 / 1021
页数：7
相关论文
共 65 条
[11]  
BRANTZAWADZKI M, 1985, AM J NEURORADIOL, V6, P675
[12]   A WHITE MATTER DISORDER IN DEMENTIA OF THE ALZHEIMER TYPE - A PATHOANATOMICAL STUDY [J].
BRUN, A ;
ENGLUND, E .
ANNALS OF NEUROLOGY, 1986, 19 (03) :253-262
[13]   MAGNETIC-RESONANCE IMAGING IN PRE-SENILE DEMENTIA OF THE ALZHEIMER-TYPE, MULTI-INFARCT DEMENTIA AND KORSAKOFFS SYNDROME [J].
CHRISTIE, JE ;
KEAN, DM ;
DOUGLAS, RHB ;
ENGLEMAN, HM ;
STCLAIR, D ;
BLACKBURN, IM .
PSYCHOLOGICAL MEDICINE, 1988, 18 (02) :319-329
[14]  
DIAZ JF, 1991, ARCH NEUROL, V48
[15]   NUCLEAR-MAGNETIC-RESONANCE IMAGING AND SINGLE PHOTON-EMISSION TOMOGRAPHY WITH RADIOIODINE LABELED COMPOUNDS IN THE DIAGNOSIS OF DEMENTIA [J].
EBMEIER, KP ;
BESSON, JAO ;
CRAWFORD, JR ;
PALIN, AN ;
GEMMEL, HG ;
SHARP, PF ;
CHERRYMAN, GR ;
SMITH, FW .
ACTA PSYCHIATRICA SCANDINAVICA, 1987, 75 (05) :549-556
[16]   DO WHITE MATTER CHANGES ON MRI AND CT DIFFERENTIATE VASCULAR DEMENTIA FROM ALZHEIMERS-DISEASE [J].
ERKINJUNTTI, T ;
KETONEN, L ;
SULKAVA, R ;
SIPPONEN, J ;
VUORIALHO, M ;
IIVANAINEN, M .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1987, 50 (01) :37-42
[17]   WHITE MATTER LOW ATTENUATION ON CT IN ALZHEIMERS-DISEASE [J].
ERKINJUNTTI, T ;
SULKAVA, R ;
PALO, J ;
KETONEN, L .
ARCHIVES OF GERONTOLOGY AND GERIATRICS, 1989, 8 (01) :95-104
[18]   CT IN THE DIFFERENTIAL-DIAGNOSIS BETWEEN ALZHEIMERS-DISEASE AND VASCULAR DEMENTIA [J].
ERKINJUNTTI, T ;
KETONEN, L ;
SULKAVA, R ;
VUORIALHO, M ;
PALO, J .
ACTA NEUROLOGICA SCANDINAVICA, 1987, 75 (04) :262-270
[19]   WHITE MATTER SIGNAL ABNORMALITIES IN NORMAL INDIVIDUALS - CORRELATION WITH CAROTID ULTRASONOGRAPHY, CEREBRAL BLOOD-FLOW MEASUREMENTS, AND CEREBROVASCULAR RISK-FACTORS [J].
FAZEKAS, F ;
NIEDERKORN, K ;
SCHMIDT, R ;
OFFENBACHER, H ;
HORNER, S ;
BERTHA, G ;
LECHNER, H .
STROKE, 1988, 19 (10) :1285-1288
[20]  
FAZEKAS F, 1989, J NUCL MED, V30, P1607
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