INTERLEUKIN-3 AS A TROPHIC FACTOR FOR CENTRAL CHOLINERGIC NEURONS INVITRO AND INVIVO

被引：131

作者：

KAMEGAI, M

NIIJIMA, K

KUNISHITA, T

NISHIZAWA, M

OGAWA, M

ARAKI, M

UEKI, A

KONISHI, Y

TABIRA, T

机构：

[1] JICHI MED SCH, DEPT NEUROL, MINAMI KAWACHI, TOCHIGI 32904, JAPAN

[2] JICHI MED SCH, DEPT ANAT, MINAMI KAWACHI, TOCHIGI 32904, JAPAN

来源：

NEURON | 1990年 / 4卷 / 03期

基金：

日本科学技术振兴机构;

关键词：

D O I：

10.1016/0896-6273(90)90055-K

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have found that interleukin 3 (IL-3), a growth factor for hematopoietic cells, is a novel trophic factor for mouse and rat central cholinergic neurons. It enhanced neurite outgrowth and elevated choline acetyltransferase activity. The effect seems to be specific for cholinergic neurons, since somatostatin release and glutamic acid decarboxylase and 2′,3′-cyclic nucleotide 3′-phosphodiesterase activities were not significantly influenced by IL-3. In vivo, IL-3 was infused into the lateral ventricles of rats after unilateral axotomy of the septohippocampal pathways. Two weeks later, the IL-3-treated animals showed significant numbers of acetylcholinesterase-positive neurons remaining in the septa[ region. © 1990.

引用

页码：429 / 436

页数：8

共 47 条

[41] INTERLEUKIN-3 STIMULATES PROLIFERATION VIA PROTEIN KINASE-C ACTIVATION WITHOUT INCREASING INOSITOL LIPID TURNOVER [J].