HUMAN HERPES-VIRUS INFECTIONS AND ALZHEIMERS-DISEASE

被引：58

作者：

DEATLY, AM

HAASE, AT

FEWSTER, PH

LEWIS, E

BALL, MJ

机构：

[1] UNIV MINNESOTA,DEPT MICROBIOL,MINNEAPOLIS,MN 55455

[2] UNIV WESTERN ONTARIO,DEPT PATHOL,LONDON N6A 3K7,ONTARIO,CANADA

[3] UNIV WESTERN ONTARIO,DEPT CLIN NEUROL SCI,LONDON N6A 3K7,ONTARIO,CANADA

[4] UNIV WESTERN ONTARIO,DEPT PSYCHIAT,LONDON N6A 3K7,ONTARIO,CANADA

来源：

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY | 1990年 / 16卷 / 03期

关键词：

herpes simplex virus‐1 latency; in situ hybridization; latency associated transcripts; reactivation;

D O I：

10.1111/j.1365-2990.1990.tb01158.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Human herpes virus infections and Alzheimer's Disease. Herpes viruses cause acute and chronic diseases of the peripheral and central nervous systems and have been implicated in the aetiology of Alzheimer's disease (AD). In this investigation the relevance of human herpes virus infection to AD was assessed by in situ hybridization. The abundant latency associated transcript(s) of herpes simplex virus type 1 (HSV‐1) were detected at a significantly higher incidence in the trigeminal ganglia of individuals with AD than in controls. But we could find no evidence of viral RNA in the central nervous system (CNS), looking specifically in the hippo‐campal cortex of demented individuals with extensive neuropathological changes of AD. These studies solve one problem in testing the viral hypothesis of causation, i.e. the sensitivity of the methods used in the search for latent infection. But the central issue remains unresolved because of necessity, only the end stage of a prolonged pathophysiological process has been examined. Our conclusions are qualified accordingly. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：213 / 223

页数：11

共 47 条

[31] ISOLATION OF HERPESVIRUSES FROM TRIGEMINAL GANGLIA OF MAN, MONKEYS, AND CATS [J].