eNOS and stroke: prevention, treatment and recovery

被引：6

作者：

Gertz, Karen ^{[1
]}

Endres, Matthias ^{[2
,3
,4
]}

机构：

[1] Charite Univmed Berlin, Klin & Poliklin Neurol, Abt Expt Neurol, Charitepl 1, D-10117 Berlin, Germany

[2] Charite Univmed Berlin, Klin & Hochschulambulanz Neurol, D-10117 Berlin, Germany

[3] Klin Neurophysiol, D-10117 Berlin, Germany

[4] Ctr Stroke Res Berlin, D-10117 Berlin, Germany

来源：

FUTURE NEUROLOGY | 2008年 / 3卷 / 05期

关键词：

endothelial nitric oxide synthase; ischemic stroke; nitric oxide;

D O I：

10.2217/14796708.3.5.537

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

It is common knowledge that ischemic stroke has major social and economic consequences. However, until now, translation of experimental studies into clinical reality has been sorely lacking. So far, most studies have focused on acute stroke outcome and early treatment paradigms affording neuroprotection. It is increasingly recognized that it will be necessary to harness the capacity of the brain for neuroregeneration to improve longerterm outcome. Endothelial nitric oxide synthase (eNOS) is emerging as a key target in molecular stroke research. eNOS ameliorates acute ischemic injury and promotes recovery following cerebral ischemia. This review summarizes the effects of eNOS on the regulation of cerebral blood flow, hemostasis, inflammation, angiogenesis as well as neurogenesis. The possible impact on stroke prevention as well as on strategies aimed at improving long-term stroke outcome are discussed.

引用

页码：537 / 550

页数：14

共 146 条

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