Anti-tumor chemotherapeutic agents induce developmental disorders of tooth germ

被引：2

作者：

Yamamoto, Toshiro ^{[1
]}

Kita, Masakazu ^{[2
]}

Mori, Masahiko ^{[3
]}

Akamatsu, Yuki ^{[1
]}

Ichioka, Hiroaki ^{[1
,2
]}

Iehara, Tomoko ^{[4
]}

Hosoi, Hajime ^{[4
]}

Kanamura, Narisato ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Dent Med, Kamigyo Ku, 465 Kajii Cho, Kyoto 6028566, Japan

[2] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Microbiol, Kyoto, Japan

[3] Asahi Univ, Sch Dent, Dept Oral & Maxillofacial Surg, Div Oral Pathogenesis & Dis Control, Gifu 5010296, Japan

[4] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Pediat, Kyoto 6028566, Japan

来源：

JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY MEDICINE AND PATHOLOGY | 2012年 / 24卷 / 04期

关键词：

Chemotherapy; Neuroblastoma; Children; Tooth germ; Side effect;

D O I：

10.1016/j.ajoms.2012.05.007

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Multi-chemotherapies for adrenal neuroblastomas have resulted in complete remission of the target tumor. At the same time, disappearance of tooth germs was observed by X-ray examination under 3 years of age. The present study presents 11 patients with adrenal neuroblastoma who received multi-drug chemotherapy and all patients remain alive. X-ray images revealed tooth germ defects in the premolar area. Deciduous teeth that fell out were examined for electron microanalysis to detect metal, including chemotherapeutic agents and crystallization in tooth hard tissue. There are no metals into dental hard tissues and also crystallization is not inhibited by chemotherapy. It was concluded that anti-tumor chemotherapeutic agents could induce both odontoblasts and ameloblasts by dysfunction of odontogenesis before the matrix-forming stage at the same concentration of chemotherapeutic agents required for complete remission of neuroblastoma. (C) 2012 Asian Association of Oral and Maxillofacial Surgeons. Published by Elsevier Ltd. All rights reserved.

引用

页码：208 / 212

页数：5

共 12 条

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