A life course approach to cardiovascular aging

被引：1
作者：
Hardy, Rebecca [1 ]
Lawlor, Debbie A. [2 ]
Kuh, Diana [1 ]
机构：
[1] UCL, MRC Unit Lifelong Hlth & Ageing, 33 Bedford Pl, London WC1B 5JU, England
[2] Univ Bristol, MRC Integrat Epidemiol Unit, Bristol BS8 2BN, Avon, England
来源：
FUTURE CARDIOLOGY | 2015年 / 11卷 / 01期
基金：
英国医学研究理事会;
关键词：
adiposity; birth weight; blood pressure; cardiovascular disease; cohort studies; glucose; life course; lipids; longitudinal modeling; social inequalities;
D O I：
10.2217/FCA.14.67
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A life course approach in epidemiology investigates the biological, behavioral and social pathways that link physical and social exposures and experiences during gestation, childhood, adolescence and adult life, and across generations, to later-life health and disease risk. We illustrate how a life course approach has been applied to cardiovascular disease, highlighting the evidence in support of the early origins of disease risk. We summarize how trajectories of cardiometabolic risk factors change over the life course and suggest that understanding underlying 'normal' or 'healthy' trajectories and the characteristics that drive deviations from such trajectories offer the potential for early prevention and for identifying means of preventing future disease.
引用
收藏
页码：101 / 113
页数：13
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