EFFECT OF SODIUM LAURYL SULFATE (SLS) ON IN-VITRO PERCUTANEOUS PENETRATION OF WATER, HYDROCORTISONE AND NICKEL

被引：20

作者：

FRANKILD, S

ANDERSEN, KE

NIELSEN, GD

机构：

[1] ODENSE UNIV HOSP,DEPT DERMATOVENEREOL,DK-5000 ODENSE C,DENMARK

[2] ODENSE UNIV,DEPT ENVIRONM MED,ODENSE,DENMARK

来源：

CONTACT DERMATITIS | 1995年 / 32卷 / 06期

关键词：

SODIUM LAURYL SULFATE; SLS; TRITIATED WATER; HYDROCORTISONE; NICKEL; IN VITRO; PERCUTANEOUS PENETRATION; SURFACTANTS; DETERGENTS;

D O I：

10.1111/j.1600-0536.1995.tb00622.x

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The dose- and time-related effect of sodium lauryl sulfate (SLS) on in vitro percutaneous penetration was studied using 3 radiolabeled tracer compounds with different physicochemical properties: tritiated water, hydrocortisone and nickel. Human cadaver abdominal skin from caucasian women was used as membrane in static in vitro penetration cells. Simultaneous application of SLS together with 1 of the tracer compounds showed, after 48 h, a significant dose-effect relationship between SLS concentration (0.25%, 2% and 10%) and penetration of tritiated water or nickel (p<0.001, Spearman), whereas SLS had no significant effect on penetration of hydrocortisone. When 4% SLS was applied as pretreatment, a significant time-effect relationship, after 48 h, was found between pretreatment time (0.5, 2 and 8 h) and penetration of tritiated water. A similar relationship was not found for penetration of nickel or hydrocortisone. Pretreatment of the skin with SLS for 2 h using 3 concentrations (0.25%, 4% and 10%) showed, after 48 h, a significant dose-effect relationship between SLS treatment and penetration of tritiated water or nickel (p<0.001, Spearman). Pretreatment had no effect on penetration of hydrocortisone. Pretreatment simulates a cleaning-washing situation. The present in vitro skin penetration model, using human cadaver skin, described the dose-effect and time-effect relationships for SLS on the penetration profiles of 3 different compounds. The model may be extended to other compounds with suspected irritant/damaging effect on the skin barrier. It should be kept in mind that the model uses a dead skin membrane without the barrier repair mechanisms of live skin.

引用

页码：338 / 345

页数：8

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