LOSS OF FUNCTION MUTATION IN THE YEAST MULTIPLE-DRUG RESISTANCE GENE PDR5 CAUSES A REDUCTION IN CHLORAMPHENICOL EFFLUX

被引：39
作者：
LEONARD, PJ
RATHOD, PK
GOLIN, J
机构：
[1] CATHOLIC UNIV AMER,DEPT BIOL,WASHINGTON,DC 20064
[2] ALLENTOWN COLL,DEPT BIOL,CENTER VALLEY,PA 18034
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 10期
关键词：
D O I：
10.1128/AAC.38.10.2492
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The yeast (Saccharomyces cerevisiae) PDRS gene product encodes a 160-kDa protein related to the large ABC family of transporters, including the human MDR1 multidrug resistance p-glycoprotein. Loss of function mutations in PDRS result in chloramphenicol hypersensitivity. A pdr5::Tn5 loss of function mutant exhibits a markedly impaired efflux of chloramphenicol compared with that of an isogenic PDRS (wild-type) control.
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页码：2492 / 2494
页数：3
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