CURCACYCLINE-A - A NOVEL CYCLIC OCTAPEPTIDE ISOLATED FROM THE LATEX OF JATROPHA-CURCAS L

被引：73
作者：
VANDENBERG, AJJ
HORSTEN, SFAJ
KETTENESVANDENBOSCH, JJ
KROES, BH
BEUKELMAN, CJ
LEEFLANG, BR
LABADIE, RP
机构：
[1] UNIV UTRECHT, FAC PHARM, DEPT PHARMACEUT ANAL, 3508 TB UTRECHT, NETHERLANDS
[2] UNIV UTRECHT, FAC CHEM, BIJVOET CTR, DEPT NMR SPECT, 3508 TB UTRECHT, NETHERLANDS
来源：
FEBS LETTERS | 1995年 / 358卷 / 03期
关键词：
JATROPHA CARCAS; EUPHORBIACEAE; CURCACYCLINE A; CYCLIC PEPTIDE;
D O I：
10.1016/0014-5793(94)01405-P
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
From the latex of Jatropha curcas L. (Euphorbiaceae) a novel cyclic octapeptide was isolated, which we named curcacycline A. The compound was found to contain one threonine, one valine, two glycine, and four leucine residues. By two-dimensional H-1-NMR spectroscopy (HOHAHA and ROESY), its sequence was determined to be Gly(1)-Leu(2)-Leu(3)-Gly(4)-Thr(5)-Val(6)-Leu(7)-Leu(8)-Gly(1). Curcacycline A displays a moderate inhibition of (i) classical pathway activity of human complement and (ii) proliferation of human T-cells.
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页码：215 / 218
页数：4
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