LEVEL OF CORTICOSTERONE REPLACEMENT DETERMINES BODY-WEIGHT GAIN IN ADRENALECTOMIZED RATS WITH VMH LESIONS

被引：8

作者：

KING, BM ^{[1
]}

ZANSLER, CA ^{[1
]}

TATFORD, AC ^{[1
]}

NEVILLE, KL ^{[1
]}

SAM, H ^{[1
]}

KASS, JM ^{[1
]}

DALLMAN, MF ^{[1
]}

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT PHYSIOL,SAN FRANCISCO,CA 94143

来源：

PHYSIOLOGY & BEHAVIOR | 1993年 / 54卷 / 06期

关键词：

VENTROMEDIAL HYPOTHALAMUS; ADRENALECTOMY; CORTICOSTERONE; BODY WEIGHT; FOOD INTAKE; ACTH; INSULIN;

D O I：

10.1016/0031-9384(93)90346-H

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Adrenalectomized female rats with lesions of the ventromedial hypothalamus or sham lesions were given SC implants of wax pellets or a fused mixture of corticosterone-cholesterol (40, 75, or 130% by weight). In animals with sham lesions, high dosages of corticosterone proved to be catabolic (r = -0.61 between plasma corticosterone and weight change). In marked contrast, animals with VMH lesions displayed substantial weight gains at all circulating levels of corticosterone, with a significant positive correlation (r = +0.48) between these two variables. It is concluded that: a) damage to the basomedial hypothalamus alters an organism's response to corticosterone at both ends of the dose-response curve, and b) both Type I and Type II corticosterone receptors in the brain play a role in hypothalamic obesity.

引用

页码：1187 / 1190

页数：4

共 29 条

[11] DIABETES-INDUCED RESISTANCE OF VENTROMEDIAL HYPOTHALAMUS TO DAMAGE BY GOLD THIOGLUCOSE - REVERSAL BY ADRENALECTOMY [J].

DEBONS, AF ;

KRIMSKY, I ;

FROM, A ;

PATTINIA.H .

ENDOCRINOLOGY, 1974, 95 (06) :1636-1641

[12] CORTICOSTERONES DUAL METABOLIC ACTIONS [J].

DEVENPORT, L ;

KNEHANS, A ;

SUNDSTROM, A ;

THOMAS, T .

LIFE SCIENCES, 1989, 45 (15) :1389-1396

[13] MIMICKING CORTICOSTERONES DAILY RHYTHM WITH SPECIFIC RECEPTOR AGONISTS - EFFECTS ON FOOD, WATER, AND SODIUM-INTAKE [J].

DEVENPORT, L ;

STITH, R .

PHYSIOLOGY & BEHAVIOR, 1992, 51 (06) :1247-1255

[14] A REEXAMINATION OF THE EFFECTS OF INTRACEREBROVENTRICULAR GLUCOCORTICOIDS IN ADRENALECTOMIZED RATS [J].

KAMARA, KS ;

KAMARA, AK ;

CASTONGUAY, TW .

BRAIN RESEARCH BULLETIN, 1992, 29 (3-4) :355-358

[15] HYPOTHALAMIC OBESITY AFTER HYPOPHYSECTOMY OR ADRENALECTOMY - DEPENDENCE ON CORTICOSTERONE [J].

KING, BM ;

SMITH, RL .

AMERICAN JOURNAL OF PHYSIOLOGY, 1985, 249 (05) :R522-R526

[16] RELATIONSHIP BETWEEN PLASMA-CORTICOSTERONE AND INSULIN LEVELS IN RATS WITH VENTROMEDIAL HYPOTHALAMIC-LESIONS [J].

KING, BM ;

CALVERT, CB ;

ESQUERRE, KR ;

KAUFMAN, JH ;

FROHMAN, LA .

PHYSIOLOGY & BEHAVIOR, 1984, 32 (06) :991-994

[17] HYPOTHALAMIC HYPERINSULINEMIA AND OBESITY - ROLE OF ADRENAL GLUCOCORTICOIDS [J].

KING, BM ;

BANTA, AR ;

THAREL, GN ;

BRUCE, BK ;

FROHMAN, LA .

AMERICAN JOURNAL OF PHYSIOLOGY, 1983, 245 (02) :E194-E199

[18] GLUCOCORTICOIDS AND HYPOTHALAMIC OBESITY [J].

KING, BM .

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 1988, 12 (01) :29-37

[19]

KING BM, 1991, METHODS NEUROSCIENCE, V7, P90

[20]

KREIGER DT, 1980, ENDOCRINOLOGY, V106, P649

← 1 2 3 →