LEVEL OF CORTICOSTERONE REPLACEMENT DETERMINES BODY-WEIGHT GAIN IN ADRENALECTOMIZED RATS WITH VMH LESIONS

被引:8
作者
KING, BM [1 ]
ZANSLER, CA [1 ]
TATFORD, AC [1 ]
NEVILLE, KL [1 ]
SAM, H [1 ]
KASS, JM [1 ]
DALLMAN, MF [1 ]
机构
[1] UNIV CALIF SAN FRANCISCO,DEPT PHYSIOL,SAN FRANCISCO,CA 94143
关键词
VENTROMEDIAL HYPOTHALAMUS; ADRENALECTOMY; CORTICOSTERONE; BODY WEIGHT; FOOD INTAKE; ACTH; INSULIN;
D O I
10.1016/0031-9384(93)90346-H
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Adrenalectomized female rats with lesions of the ventromedial hypothalamus or sham lesions were given SC implants of wax pellets or a fused mixture of corticosterone-cholesterol (40, 75, or 130% by weight). In animals with sham lesions, high dosages of corticosterone proved to be catabolic (r = -0.61 between plasma corticosterone and weight change). In marked contrast, animals with VMH lesions displayed substantial weight gains at all circulating levels of corticosterone, with a significant positive correlation (r = +0.48) between these two variables. It is concluded that: a) damage to the basomedial hypothalamus alters an organism's response to corticosterone at both ends of the dose-response curve, and b) both Type I and Type II corticosterone receptors in the brain play a role in hypothalamic obesity.
引用
收藏
页码:1187 / 1190
页数:4
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