EFFECTS OF L-TRYPTOPHAN ON THE DEVELOPMENT OF TOLERANCE TO THE ANTITUSSIVE EFFECTS OF DIHYDROCODEINE

被引：0
作者：
KAMEI, J
MORI, T
KASUYA, Y
机构：
[1] Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo 142, 4-41
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 1991年 / 55卷 / 03期
关键词：
D O I：
10.1254/jjp.55.403
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effects of L-tryptophan on the development of tolerance to the antitussive effects of dihydrocodeine were examined in rats. Chronic co-administration of L-tryptophan with dihydrocodeine prevented the development of tolerance to the antitussive effects of dihydrocodeine. Furthermore, the antitussive effects of dihydrocodeinc in dihydrocodeine-tolerant rats were fully restored by acute co-administration of L-tryptophan, as evidenced by a decrease of about 50% in the ED50 value of dihydrocodeine. Thus, it is concluded that L-tryptophan may antagonize the development of tolerance to the antitussive effects of dihydrocodeine.
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页码：403 / 406
页数：4
相关论文
共 11 条
[1]   MODIFICATION OF SEROTONIN METABOLISM IN RAT-BRAIN AFTER ACUTE OR CHRONIC ADMINISTRATION OF MORPHINE [J].
HAUBRICH, DR ;
BLAKE, DE .
BIOCHEMICAL PHARMACOLOGY, 1973, 22 (21) :2753-2759
[2]   EFFECTS OF L-TRYPTOPHAN ON THE EFFECTS OF ANTITUSSIVES [J].
KAMEI, J ;
MORI, T ;
KASUYA, Y .
JOURNAL OF PHARMACOBIO-DYNAMICS, 1990, 13 (04) :231-237
[3]   SUBSENSITIVITY TO THE COUGH-DEPRESSANT EFFECTS OF OPIOID AND NONOPIOID ANTITUSSIVES IN MORPHINE-DEPENDENT RATS - RELATIONSHIP TO CENTRAL SEROTONIN FUNCTION [J].
KAMEI, J ;
MORI, T ;
OGAWA, M ;
KASUYA, Y .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1989, 34 (03) :595-598
[4]   SUPERSENSITIVITY OF 5,7-DIHYDROXYTRYPTAMINE-TREATED RATS TO THE RESPIRATORY DEPRESSANT AND ANTITUSSIVE EFFECTS OF DIHYDROCODEINE [J].
KAMEI, J ;
OGAWA, M ;
KASUYA, Y .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1988, 153 (2-3) :305-308
[5]  
KAMEI J, 1987, ARCH INT PHARMACOD T, V290, P117
[6]   EFFECTS OF METHYSERGIDE ON THE COUGH REFLEX [J].
KAMEI, J ;
HOSOKAWA, T ;
YANAURA, S ;
HUKUHARA, T .
JAPANESE JOURNAL OF PHARMACOLOGY, 1986, 42 (03) :450-452
[7]  
MARUYAMA Y, 1971, J PHARMACOL EXP THER, V178, P20
[8]   REDUCTION IN THE NUMBER OF SEROTONIN RECEPTORS IN THE BRAIN-STEM OF MORPHINE-DEPENDENT RATS - RELATION TO BLOCKADE OF NALOXONE PRECIPITATED JUMPING BY SEROTONIN AGONISTS [J].
SAMANIN, R ;
CERVO, L ;
ROCHAT, C ;
POGGESI, E ;
MENNINI, T .
LIFE SCIENCES, 1980, 27 (13) :1141-1146
[9]  
SHEN FH, 1970, J PHARMACOL EXP THER, V175, P427
[10]  
SUZUKI T, 1983, PROG NEURO-PSYCHOPH, V7, P63
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