EFFECT OF GALANIN ON GROWTH-HORMONE (GH) RESPONSE TO THYROTROPIN-RELEASING-HORMONE OF RAT PITUITARY GH-SECRETING ADENOMATOUS CELLS (GH(1)) IN CULTURE

被引：4

作者：

GIUSTINA, A ^{[1
]}

BONFANTI, C ^{[1
]}

LICINI, M ^{[1
]}

STEFANA, B ^{[1
]}

RAGNI, G ^{[1
]}

TURANO, A ^{[1
]}

机构：

[1] UNIV BRESCIA,SCH MED,INST MICROBIOL,I-25123 BRESCIA,ITALY

来源：

LIFE SCIENCES | 1995年 / 58卷 / 01期

关键词：

GALANIN; TRH; GH(1) CELLS;

D O I：

10.1016/0024-3205(95)02258-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The growth hormone (GH) releasing effect of thyrotropin-releasing hormone (TRH) and galanin, a 29-amino acid peptide widely distributed in mammalian CNS, alone or in combination was investigated in cultured rat pituitary tumor cells (GH(1)). TRH stimulated GH secretion in GH(1) cells (maximal stimulation at the dose of 0.1 mu M). Galanin alone had a significant GH inhibitory effect in GH(1) cells at all the doses used. When the two peptides were administered in combination, no significant changes as compared to baseline levels were observed. The results of this study indicate that galanin has potent direct inhibitory effects on baseline and TRH-stimulated GH release from rat tumor cells.

引用

页码：83 / 90

页数：8

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