CHANGES IN THE VIRULENCE OF MYCOBACTERIUM-BOVIS (BCG PHIPPS) IN CARBON-TETRACHLORIDE TREATED MICE

被引:0
作者
GUPTA, HP [1 ]
SRIVASTAVA, A [1 ]
SINGH, NB [1 ]
机构
[1] CENT DRUG RES INST,DIV MICROBIOL,LUCKNOW 226001,UTTAR PRADESH,INDIA
关键词
BCG; CARBON TETRACHLORIDE; LIVER; NECROSIS; VIRULENCE;
D O I
暂无
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Mild grade of liver damage was produced in mice by repeated subcutaneous injection of carbon tetrachloride. These mice alongwith saline treated mice were challenged with an avirulent vaccine strain of BCG (Phipps), intravenously. The CCl4 treated, BCG challenged mire developed disease and died much earlier than the controls, indicating an increased susceptibility to the avirulent strain in mice with mild hepatitis.
引用
收藏
页码:163 / 166
页数:4
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