LOW-RISK OF VIRAL-INFECTION AFTER ADMINISTRATION OF VAPOR-HEATED FACTOR-VIII CONCENTRATE

被引：50

作者：

MANNUCCI, PM

SCHIMPF, K

ABE, T

ALEDORT, LM

ANDERLE, K

BRETTLER, DB

HILGARTNER, MW

KERNOFF, PBA

KUNSCHAK, M

MCMILLAN, CW

PRESTON, FE

RIVARD, GE

机构：

[1] ANGELO BIANCHI BONOMI HEMOPHILIA & THROMBOSIS CTR,MILAN,ITALY

[2] REHABIL FDN,REHABIL HOSP & HEMOPHILIA CTR HEIDELBERG,HEIDELBERG,GERMANY

[3] TEIKYO UNIV,SCH MED,DEPT MED,TOKYO 173,JAPAN

[4] CUNY MT SINAI SCH MED,DEPT MED,NEW YORK,NY 10029

[5] IMMUNO AG WIEN,VIENNA,AUSTRIA

[6] MED CTR CENT MASSACHUSETTS,NEW ENGLAND COMPREHENS HEMOPHILIA CTR,WORCESTER,MA

[7] CORNELL UNIV,SCH MED,DEPT PEDIAT,ITHACA,NY 14853

[8] ROYAL FREE HOSP,CTR HEMOPHILIA,LONDON,ENGLAND

[9] ROYAL FREE HOSP,HEMOSTASIS UNIT,LONDON,ENGLAND

[10] UNIV N CAROLINA,SCH MED,DEPT PEDIAT,CHAPEL HILL,NC 27514

[11] ROYAL HALLAMSHIRE HOSP,DEPT HEMATOL,SHEFFIELD S10 2JF,S YORKSHIRE,ENGLAND

[12] HOSP ST JUSTINE,MONTREAL,QUEBEC,CANADA

来源：

TRANSFUSION | 1992年 / 32卷 / 02期

关键词：

D O I：

10.1046/j.1537-2995.1992.32292180141.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A multicenter prospective study was carried out to evaluate whether a vapor-heated factor VIII concentrate transmitted blood-borne viral infections over a surveillance period of 15 months. Thirty-five patients with hemophilia and von Willebrand disease who had never received any blood components were treated. Twenty-eight were analyzed and found not to have non-A,non-B hepatitis. Sera from 20 of these 28 patients were also tested for the antibody to the hepatitis C virus. None had seroconverted during the follow-up period. None of the patients analyzed developed markers of the hepatitis B virus (n = 17) or the human immunodeficiency virus (n = 31). This vapor-heated factor VIII concentrate carries a low risk of transmitting hepatitis and human immunodeficiency virus infection.

引用

页码：134 / 138

页数：5

共 20 条

[1] DETECTION OF ANTIBODY TO HEPATITIS-C VIRUS IN PROSPECTIVELY FOLLOWED TRANSFUSION RECIPIENTS WITH ACUTE AND CHRONIC NON-A-HEPATITIS, NON-B-HEPATITIS [J].