NEONATAL BARTTERS-SYNDROME - A 20 YEARS FOLLOW-UP

Bartter's syndrome is general atributted to a primary defect in salt reabsorption in the proximal tubule, limb of Henle's loop or distal tubule. We have studied salt and water reabsorption in the different tubular segments by producing acute expansion of the blood volume with hypotonic fluid in a patient with Bartter's syndrome diagnosticated at 5 months of age. These studies were carried out on four occasions when the patient was 7, 11, 15, and 19 years old. The first study demonstrate important proximal and distal defect in salt reabsorption. The proximal tubular disfunction dissapeared when the patient was eleven years old.