INTERACTION OF CALCIUM AND PHOSPHATE DECREASES ILEAL MAGNESIUM SOLUBILITY AND APPARENT MAGNESIUM ABSORPTION IN RATS

被引:89
|
作者
BRINK, EJ
BEYNEN, AC
DEKKER, PR
VANBERESTEIJN, ECH
VANDERMEER, R
机构
[1] UNIV UTRECHT,DEPT LAB ANIM SCI,UTRECHT,NETHERLANDS
[2] AGR UNIV WAGENINGEN,DEPT HUMAN NUTR,6700 HB WAGENINGEN,NETHERLANDS
来源
JOURNAL OF NUTRITION | 1992年 / 122卷 / 03期
关键词
MAGNESIUM; ABSORPTION; SOLUBILITY; RATS;
D O I
10.1093/jn/122.3.580
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
We tested the hypothesis that increased intakes of calcium and phosphate lower magnesium solubility in the intestinal lumen, causing a decreased magnesium absorption. In in vitro experiments at a constant magnesium concentration, increasing calcium concentrations reduced magnesium solubility. This effect did not occur in the absence of phosphate. Increasing phosphate concentrations decreased the solubility of magnesium in the presence, but not in the absence, of calcium. These results suggest that the formation of an insoluble calcium-magnesium-phosphate complex determines magnesium solubility. To extend this concept to in vivo conditions, rats were fed purified diets containing a constant concentration of magnesium (16.4-mu-mol/g) but different concentrations of calcium (25, 100 or 175-mu-mol/g) and phosphate (58, 103 or 161-mu-mol/g). Increased intakes of calcium decreased magnesium solubility in the ileal lumen and lowered magnesium absorption. The latter result occurred only if the dietary phosphate concentration was at least 103-mu-mol/g. Increasing dietary phosphate concentrations reduced both magnesium solubility in the ileum and magnesium absorption, but only if the dietary calcium concentration was at least 100-mu-mol/g. These results support those obtained in vitro. We conclude that increased intakes of calcium and phosphate decrease magnesium absorption by the formation of an insoluble calcium-magnesium-phosphate complex in the intestinal lumen.
引用
收藏
页码:580 / 586
页数:7
相关论文
共 50 条
  • [31] INSULIN EFFECTS ON CALCIUM, MAGNESIUM AND PHOSPHATE-METABOLISM IN RATS
    MELLERUP, ET
    ACTA ENDOCRINOLOGICA, 1974, 75 (04): : 748 - 755
  • [32] EFFECT OF DIETARY CALCIUM, MAGNESIUM, AND PHOSPHORUS ON PHOSPHATE UROLITHIASIS IN RATS
    CHOW, FHC
    TATON, GF
    BOULAY, JP
    LEWIS, LD
    REMMENGA, EE
    HAMAR, DW
    INVESTIGATIVE UROLOGY, 1980, 17 (04): : 273 - 276
  • [33] LITHIUM EFFECTS ON MAGNESIUM, CALCIUM, AND PHOSPHATE-METABOLISM IN RATS
    MELLERUP, ET
    PLENGE, P
    INTERNATIONAL PHARMACOPSYCHIATRY, 1976, 11 (03): : 190 - 195
  • [34] INSULIN EFFECTS ON PHOSPHATE, MAGNESIUM, AND CALCIUM-METABOLISM IN RATS
    MELLERUP, ET
    RAFAELSEN, OJ
    EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1973, 3 (03) : 255 - 255
  • [35] SOLUBILITY PRODUCT OF MAGNESIUM AND CALCIUM SELENITES
    SAVENKO, VS
    ZHURNAL NEORGANICHESKOI KHIMII, 1995, 40 (08): : 1254 - 1256
  • [36] EFFECT OF ALANINE AND DIMETHYL-SULFOXIDE ON SOLUBILITY OF CALCIUM-PHOSPHATE, MAGNESIUM PHOSPHATE AND CALCIUM-OXALATE
    HAMAR, DW
    HUANG, S
    CHENCHOW, FH
    BIOCHEMICAL MEDICINE, 1974, 11 (01): : 98 - 102
  • [37] Hydroxypropyl-distarch phosphate from tapioca starch reduces zinc and iron absorption, but not calcium and magnesium absorption, in rats
    Kishida, T
    Nakai, Y
    Ebihara, K
    JOURNAL OF NUTRITION, 2001, 131 (02): : 294 - 300
  • [38] Mannitol improves absorption and retention of calcium and magnesium in growing rats
    Xiao, Jin
    Li, Xiao
    Min, Xiao
    Sakaguchi, Ei
    NUTRITION, 2013, 29 (01) : 325 - 331
  • [39] Effect of high magnesium intake on apparent magnesium absorption in lactating cows
    Jittakhot, S
    Schonewille, JT
    Wouterse, H
    Focker, EJ
    Yuangklang, C
    Beynen, AC
    ANIMAL FEED SCIENCE AND TECHNOLOGY, 2004, 113 (1-4) : 53 - 60
  • [40] Effects of lactitol-oligosaccharides on calcium and magnesium absorption in rats
    Yanahira, S
    Morita, M
    Aoe, S
    Suguri, T
    Takada, Y
    Miura, S
    Nakajima, I
    JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 1997, 43 (01) : 123 - 132