INVITRO CYTOTOXICITY AND GENOTOXICITY OF ORGANOMERCURIALS TO CELLS IN CULTURE

被引：35

作者：

BABICH, H ^{[1
]}

GOLDSTEIN, SH ^{[1
]}

BORENFREUND, E ^{[1
]}

机构：

[1] YESHIVA UNIV,STERN COLL,DEPT BIOL SCI,NEW YORK,NY 10033

来源：

TOXICOLOGY LETTERS | 1990年 / 50卷 / 2-3期

关键词：

Aquatic toxicology; Bluegill sunfish; Micronucleus assay; Neutral red cytotoxicity assay;

D O I：

10.1016/0378-4274(90)90004-6

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The sequence of cytotoxic effects for a series of mercury compounds to the BG/F epithelioid cells derived from fin tissue of bluegill sunfish was phenyl mercuric chloride > methyl mercuric chloride > ethyl mercuric chloride ≫ mercuric chloride. This sequence of in vitro cytotoxicity was similar to that observed in a 48-h LC50 in vivo acute toxicity assay with rainbow trout. Using induction of micronuclei as an indicator of genetic damage, the organomercurials, but not mercuric chloride, were noted to be clastogenic to the BG/F cells. © 1990.

引用

页码：143 / 149

页数：7

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