An overview on antiepileptic drugs

被引：38
作者：
Das, Nirupam [1 ]
Dhanawat, Meenakshi [1 ]
Shrivastava, Sushant K. [1 ]
机构：
[1] Banaras Hindu Univ, Indian Inst Technol, Dept Pharmaceut, Varanasi 221005, Uttar Pradesh, India
来源：
DRUG DISCOVERIES AND THERAPEUTICS | 2012年 / 6卷 / 04期
关键词：
Epilepsy; anticonvulsants; resistance; combination therapy;
D O I：
10.5582/ddt.2012.v6.4.178
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Epilepsy is the most common chronic neurological disorder of the brain. For several decades different kinds of medications have been used to treat epilepsy. Even though many surgical advances has been made and implemented, medications remain the basis of treatment. The search for noble antiepileptic drugs (AEDs) with more selective activity and lower toxicity continues to be an area of intensive investigation in medicinal chemistry. Additionally, drug resistance is an important clinical problem in epilepsy and is associated with an increased risk of morbidity and mortality. This review intends to present a comprehensive overview on AED in particular along with discussion on some aspects of associated drug resistance and combination therapy.
引用
收藏
页码：178 / 193
页数：16
相关论文
共 142 条
[1]   Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024 [J].
Ambrósio, AF ;
Soares-da-Silva, P ;
Carvalho, CM ;
Carvalho, AP .
NEUROCHEMICAL RESEARCH, 2002, 27 (1-2) :121-130
[2]  
Bauer Jurgen, 2008, Neuropsychiatr Dis Treat, V4, P731
[3]   Introduction to zonisamide [J].
Baulac, M .
EPILEPSY RESEARCH, 2006, 68 :S3-S9
[4]   Efficacy and safety of Losigamone in partial seizures: a randomized double-blind study [J].
Baulac, M ;
Klement, S .
EPILEPSY RESEARCH, 2003, 55 (03) :177-189
[5]   Seletracetam (UCB 44212) [J].
Bennett, Barbara ;
Matagne, Alain ;
Michel, Philippe ;
Leonard, Michele ;
Cornet, Miranda ;
Meeus, Marie-Anne ;
Toublanc, Nathalie .
NEUROTHERAPEUTICS, 2007, 4 (01) :117-122
[6]   New concepts in classification of the epilepsies: Entering the 21st century [J].
Berg, Anne T. ;
Scheffer, Ingrid E. .
EPILEPSIA, 2011, 52 (06) :1058-1062
[7]   Progress report on new antiepileptic drugs: A summary of the Ninth Eilat Conference (EILAT IX) [J].
Bialer, Meir ;
Johannessen, Svein I. ;
Levy, Rene H. ;
Perucca, Emilio ;
Tomsone, Torbjorn ;
White, H. Steve .
EPILEPSY RESEARCH, 2009, 83 (01) :1-43
[8]   Adjunctive lamotrigine XR for primary generalized tonic-clonic seizures in a randomized, placebo-controlled study [J].
Biton, Victor ;
Di Memmo, Juan ;
Shukla, Rakesh ;
Lee, Yeong Yeh ;
Poverennova, Irina ;
Demchenko, Vladislav ;
Saiers, Jane ;
Adams, Bryan ;
Hammer, Anne ;
Vuong, Alain ;
Messenheimer, John .
EPILEPSY & BEHAVIOR, 2010, 19 (03) :352-358
[9]   Genetic factors associated with drug-resistance of epilepsy: Relevance of stratification by patient age and aetiology of epilepsy [J].
Blanca Sanchez, M. ;
Herranz, Jose L. ;
Leno, Carlos ;
Arteaga, Rosa ;
Oterino, Agustin ;
Valdizan, Elsa M. ;
Nicolas, Jose M. ;
Adin, Javier ;
Armijo, Juan A. .
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2010, 19 (02) :93-101
[10]  
Blaszczyk B, 2010, NEUROPSYCH DIS TREAT, V6, P145
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